摘要
采用肉瘤180(S180)、肝癌腹水型(HepA)和白血病腹水型(P388)3种小鼠移植性肿瘤模型,研究了人参皂苷—铁线莲皂苷对小鼠体内肿瘤的抑制作用。结果表明:人参皂苷—铁线莲皂苷对小鼠移植性肿瘤S180、HepA、P388均有显著的抑制作用。当剂量为0.6g/kg时,对小鼠移植性肿瘤S180、HepA和P388抑制率分别为52.41%、53.57%、54.15%(P<0.01),对小鼠生命的延长作用显著(P<0.01),对小鼠免疫器官重变化的影响不显著,说明人参皂苷—铁线莲皂苷对小鼠移植性肿瘤有显著的抑制作用。
To study the anticancer activities of the ginsenoside and clematoside mixture in vivo, test is carried out with three kinds of mice＇s transplant tumor model of sarcoma（S180）, HepA and leucocythemia ascitic type （P388）. The test shows that the mixture has remarkable inhibiting effect on mice＇s transplant tumor like S180, HepA and P388. When the dose is 0.6 g/kg, the rate of inhibiting effect on mice＇s transplant tumor like S180, HepA and P388 are 52.41%, 53.57 % and 54.15 % （ P 〈 0.01 ） respectively. ]t can remarkably prolong the life of mice （ P 〈 0.01 ）and insignificantly influence the weight variation of mice＇s immune organs, which indicates the mixture has distinct tumor inhibiting effect on mice＇s transplant tumor.
出处
《吉林农业大学学报》
CAS
CSCD
北大核心
2010年第6期654-656,660,共4页
Journal of Jilin Agricultural University
基金
吉林省科技发展计划项目(20070713)
