摘要
因血吸虫重组疫苗是一种弱免疫原，佐剂在提呈这种弱免疫原上起着十分重要的作用。本实验结果显示日本血吸虫成虫粗抗原与佐剂ＦＣＡ、Ｆｅ（ＯＨ）＋３、Ｆｅ（ＯＨ）－３、鱼油及参环毛蚓分别免疫小鼠，所得减虫率分别为３３．３９％、４１．８９％、３５．４３％、４０．３％、４８．７５％。其中，Ｆｅ（ＯＨ）－３与ＦＣＡ、Ｆｅ（ＯＨ）＋３与鱼油之间无显著性差异（Ｐ＞０．０５），但后两者效果显著优于前两者（Ｐ＜０．０１），参环毛蚓的效果又显著优于Ｆｅ（ＯＨ）＋３和鱼油（Ｐ＜０．０１）。
Adjuvant is important in passing the Schis to soma japonicum S japonicum reformed vaccine because the vaccine is a inferior antigen The results of the examination indicate∶after the rats were immuned by S japonicum antigen(S j Ag)with FCA,Fe(OH) + 3 colloid,Fe(OH) + 3 colloid,fish oil and Pheretima aspergillum (Pa),the reductions percentage of worm burden were 33 29%,41 89%,35 43%,40 3%,48 75% respectively No significant difference(P>0 05) between the groups immuned by S j Ag with FCA and Fe(OH) 3 colloid,the same to the groups immuned by Sj Ag with Fe(OH) + 3,colloid and fish oil The effect of the latter two groups is better than the former two with significant difference(P<0 01) The effect of Pa is better than the latter two groups with significant difference(P<0 01)
出处
《中国人兽共患病杂志》
CSCD
北大核心
1999年第2期21-23,共3页
Chinese Journal of Zoonoses
关键词
佐剂
日本血吸虫
疫苗
参环毛蚓
血吸虫病
Adjuvant Schistosoma japonicum vaccine Pheretima aspergillum
