摘要
目的了解急性白血病化疗患者焦虑、抑郁状况,并探讨其与患者生命质量的关系。方法应用医院焦虑抑郁量表(HAD)、癌症患者生命质量测定量表(EORTC QLQ-C30)对166例急性白血病化疗患者进行调查。结果急性白血病化疗患者中焦虑的发生率为38.6%,抑郁的发生率为27.7%;焦虑、抑郁成正相关(r=0.857,P<0.001);焦虑组患者与非焦虑组患者的生命质量总体差异有统计学意义(P<0.001),两组各子量表,如情绪功能、认知功能、社会功能、总健康状况、疲倦、恶心与呕吐、疼痛、失眠、食欲丧失、经济困难、躯体功能、呼吸困难、便秘、腹泻间差异均有统计学意义(P<0.05),但在角色功能子量表差异无统计学意义(P>0.05)。结论急性白血病患者心理问题严重,焦虑、抑郁发生率高;以焦虑为分组因素发现,有焦虑症状的患者生命质量总体水平低,且在生命质量指征的绝大多数方面表现突出。
Objective To study the state of anxiety and depression of acute leukemia patients treated with chemotherapy and explore its relation with quality of life. Methods The questionnaire surrey was conducted among acute leukemia patients treated with chemotherapy by using Hospital Anxiety and Depression Scale （HAD） and European Organization for Research and Treatment of Cancer （ EORTC QLQ - C30）. Results The incidence rate of anxiety of acute leukemia patients treated with chemotherapy was 38. 6%, the incidence rate of depression was 27.7%. Anxiety level was positively related to depression （ r = 0. 857, P 〈0. 001 ）. Compared between anxiety and non - anxiety groups there was a statistical difference in quality of life as the whole （P 〈0. 001 ） ; and there were statistical differences in such factional scales as emotional function, cognition function, social function, general health condition, fatigue, nausea, vomiting, pain, insomnia, anorexia, economic problem, somatic function, dyspnea, constipation, and diarrhea （P 〈 0.05）. However no statistical significance was found in role function （P 〉 0. 05 ） . Conclusion Psychological problems of acute leukemia patients treated with chemotherapy are severe, their incidence rates of anxiety and depression are high. The general level of quality of life of the patients with anxiety is lower, which is evident in the majority of their life indications.
出处
《中国全科医学》
CAS
CSCD
北大核心
2010年第34期3906-3908,共3页
Chinese General Practice
关键词
急性白血病
化疗
焦虑
抑郁
生命质量
Acute leukemia
Chemotherapy
Anxiety
Depression
Quality of life
