摘要
目的:综述人工韧带表面修饰技术及其在重建膝关节交叉韧带中的效果。方法:采用电子检索的方式,在万方数据库(http://www.wanfangdata.com.cn/)中检索2000-01/2010-08关于人工韧带表面修饰技术及其在重建膝关节交叉韧带应用方面的文章,关键词为"人工韧带,表面修饰,交叉韧带"。排除重复研究、普通综述或Meta分析类文章,筛选纳入33篇文献进行评价。结果:生物材料的表面修饰是一项复杂的系统工程,需要兼顾材料学和生物科学的需要,实现理想的表面修饰应该设计表面拓扑结构-特异性识别-亲水/疏水平衡-蛋白质吸附等各个方面。目前所采用的表面修饰技术主要有固定多肽法、固定蛋白质法、激光表面修饰法、辐射接枝法、离子注入法、接枝改性法。研究表明,通过生物材料表面修饰,不仅增进了细胞的黏附,而且促进了细胞的增殖。结论:人工韧带表面修饰技术在提高人工材料的生物相容性方面取得了显著效果,具有良好的应用前景。
OBJECTIVE： To review the surface modification techniques of artificial ligaments and its efficacy in reconstruction of knee joint cruciate ligament. METHODS： A computer research was performed in Wanfang database （http：//www.wanfangdata.com.cn/） from January 2000 to August 2010 to retrieve articles about the surface modification techniques of artificial ligaments and its application in reconstruction of knee joint cruciate ligament, using Key words of ＂artificial ligament, surface modification, cruciate ligament＂ in Chinese. Repeated study, general review or Meta analysis were excluded, 33 literatures were screened into the evaluation. RESULTS： The surface modification of biomaterials is a complicated system, needs both material science and biological science requirements, achieving the desired surface modification should design he surface topology structure-specific recognition-hydrophilic/hydrophobic balance-protein adsorption. Current surface modification techniques are mainly fixed peptide, fixed proteins, laser surface modification, radiation grafting, ion implantation, grafting modification. Through biological materials surface modification, cell adhesion is enhanced, cell proliferation is also promoted. CONCLUSION： The artificial ligament surface modification technology may achieve remarkable results to improve the biocompatibility of artificial materials, with a good application prospect.
出处
《中国组织工程研究与临床康复》
CAS
CSCD
北大核心
2010年第42期7915-7918,共4页
Journal of Clinical Rehabilitative Tissue Engineering Research
