摘要
目的:评价单独和联合高危型人乳头状瘤病毒(HPV-DNA)检测和宫颈液基细胞学检查(TCT)对宫颈癌及癌前病变筛查的效果。方法:对885例妇女进行HPV分型基因检测技术检测高危型HPV和TCT检查,248例在电子阴道镜下进行可疑病灶定位活检,以宫颈活检的组织病理学结果为确诊标准。结果:经病理确诊为宫颈病变的患者,高危型HPV阳性率分别为CINⅠ45.00%、CINⅡ84.00%、CINⅢ93.00%、SCC100.00%,且HPV感染与CINⅡ/Ⅲ正相关(r=0.801,P<0.01)。HPV检测CINⅡ、Ⅲ的敏感度、特异度、阳性预测值、阴性预测值分别为90.12%、71.72%、5.13%、98.26%;宫颈细胞学筛查CINⅡ、Ⅲ,以LSIL为分界点的上述4值分别是89.35%、83.66%、21.52%、99.52%;高危型HPV检测联合细胞学检查的上述4值分别是98.72%、73.48%、51.52%、100.00%。结论:HPV高危型检测是有效的宫颈癌筛查方法,联合应用TCT后敏感度和阴性预测值进一步提高,但特异度未能提高。
Objective：To evaluate the effect of single and union high risk-human papillomavirus test（HPV）and liquid based cytology（TCT） in diagnosis of cervical disease.Methods：885 cases of patients were screened by combining HPV test（HPV Genotyping system）and TCT（liquid-based ThinPrep cytology test）,248 cases were further biopsied under the colposcope and diagnosed with pathology.Results：Among the Patients with abnormal cervical lesions diagnosed with pathology,the positive rate of HPV in CINⅠwas 45%,CINⅡ84%,CINⅢ 93%,SCC100%,and were positively correlated with CINⅡ/Ⅲ（r=0.801,P〈0.01）.High risk HPV DNA test the sitivity,specificity,positive forecasting value,negative forecasting value of CINⅡ,Ⅲ were separately 90.12 %,71.72 %,5.13%,98.26 %;TCT checking CINⅡand Ⅲ,the said four value division of LSIL were separately 89.35%,83.66%,21.52%,99.52%;and the said four values of combination of HPV DNA test union TCT checking were separately 98.72%、73.48%,51.52%,100%.Conclusion：High-risk HPV DNA test is a effective method for detecting cervical disease.The combination of high-risk HPV DNA test and cytological test increases the sensitivity and negative-predictive value,but it does not increase the specificity.
出处
《中国妇幼保健》
CAS
北大核心
2010年第32期4778-4780,共3页
Maternal and Child Health Care of China
基金
金华市科技局基金项目〔2007-3-033〕
关键词
细胞学
宫颈病变
HPV
Cytology
Cervical lesion
Human papillomavirus
