摘要
目的:观察Ⅲ期鼻咽癌应用PF方案化疗同步放疗的临床效果和毒副反应。方法:将126例Ⅲ期鼻咽癌患者分为放化疗组和单放组。单放组61例,采用^(60)钴常规放疗,DT68Gy～72Gy/7周。放化疗组65例在单纯放疗的基础上联合化疗,PF方案:DDP,30mg,静脉滴注,d_(1～3),5-Fu 500mg,静脉滴注,d_(1～5),亚叶酸钙0.2静脉滴注d_(1～5)。间隔3周后重复,放疗全程中行两次化疗。结果:治疗结束后3个月进行近期疗效评价:放化疗组和单放组患者鼻咽部近期有效率分别为93.8%和93.4%,颈部近期有效率分别为95.4%和93.4%。5年生存率分别为41.5%和26.2%(P<0.05)。放化疗组和单放组的Ⅱ、Ⅲ度呕吐分别为58.5%和26.2%、厌食67.7%和49.2%、脱发73.8%和4.9%,白细胞下降72.3%和63.9%,口腔粘膜炎64.6%和64.4%。结论:两种方法对Ⅲ期鼻咽癌的近期疗效相近,远期疗效放化疗组优于单放组。
Objective： To observe the clinical efficacy and the adverse reaction of PF regimen combined with concurrent radiotherapy for stage Ⅲ nasopharyngeal carcinoma. Methods： 125 cases of nasopharyngeal carcinoma were divided into chemoradiotherapy group and radiotherapy group. The radiotherapy group（61 cases） accepted the routine radiotherapy of ^60Co 68Gy - 72Gy/7 weeks. The chemoradiotherapy group（65 cases） received chemothrapy plus routine radiotherapy. The regimen was： DDP, 30mg intravenously , d1-3,5-Fu, 500mg intravenously, d1-5, LV 0. 2 intravenously, d1-5. Chemotherapy was repeated 3 weeks later and altogether twice were conducted during the process of radiotherapy. Results： The short-term efficacy was assessed 3 months after the treatment which was 93.8% and 93.4% for the nasopharyngeal site of chemoradiotherapy group and radiotherapy group respectively and 95.4% and 93.4% for the neck site of chemoradiotherapy group and radiotherapy group respectively. The 5-year survival rate was 41.5% and 26. 2% （P 〈 0.05） for chemoradiotherapy group and radiotherapy group respectively. The common adverse reaction included Ⅱ and Ⅲ degree vomiting with the incidence of 58.5% and 26.2% , anorexia with the incidence of 67.7% and 49.2%, alopecia with the incidence of 73.8% and 4.9%, leucopenia with the incidence of 72.3% and 63.9%, mucositis with the incidence of 64.6% and 64.4% in chemoradiotherapy group and radiotherapy group respectively. Conclusion： The short-term efficacy of these two kinds of treatment for stage Ⅲ nasopharyngeal carcinoma are close while the long-term efficacy of chemoradiotherapy group is better than that of the radiotherapy group.
出处
《肿瘤预防与治疗》
2010年第6期483-485,共3页
Journal of Cancer Control And Treatment
关键词
鼻咽癌
放射治疗
化学治疗
Nasopharyngeal Carcinoma
Radiotherapy
Chemotherapy
