摘要
髓系细胞表达的触发受体1（triggering receptor expressed on myeloid cells-1,TREM-1）是一种主要表达在中性粒细胞和巨噬细胞表面的受体蛋白,属于免疫球蛋白超家族的成员.机体发生感染性疾病时,TREM-1通过其细胞内的短尾区域与其配体和跨膜蛋白DAPl2结合,激活下游信号转导通路,导致亲炎症介质如白介素8、肿瘤坏死因子α等释放增加,在炎症反应的放大过程中起着重要作用.人类感染性疾病中,以肺部感染为多,急性肺部感染时,巨噬细胞被激活,TREM-1从其表面脱落,通过检测肺泡灌洗液中sTREM-1（TREM-1的可溶性形式）的水平为肺部感染性疾病的诊断和治疗提供新的价值.本文就TREM-1与肺部疾病的关系进综述.
Triggering receptor expressed on myeloid cells-1 （TREM-1） is a receptor protein mainly expressed on the surface of neutrophils and macrophages,and belongs to the member of immunoglobulin superfamily. When infectious diseases occur in the body, TREM-1 combines with its ligand and transmembrane protein DAP12 through the short-tail region, activates downstream signal transduction pathways to lead to the increase of proinflammatory mediators such as interleukin-8, tumor necrosis factor-α,and plays an important role in the amplification process of inflammatory response. In human infectious diseases,lung infection is more common. In the acute lung infection, macrophages are activated, TREM-1 sheds from the surface. It can provide the new value for the diagnosis and treatment of lung infection diseases by detecting sTREM-1 （TREM-1 in soluble form） in the bronchoalveolar lavage fluid. This article reviews the relationship between TREM-1 and lung diseases.
出处
《国际呼吸杂志》
2010年第22期1388-1391,共4页
International Journal of Respiration
关键词
髓系细胞表达的触发受体1
肺部疾病
Triggering receptor expressed on myeloid cells-1
Lung diseases
