摘要
目的比较灯盏乙素、灯盏乙素PEG衍生物和灯盏乙素PEG衍生物配伍冰片对大鼠实验性脑缺血的防治作用。方法采用大鼠大脑中动脉线栓(MCAO)法制备局灶性脑缺血/复灌损伤模型(I/R),随机分为假手术组,模型组,灯盏乙素PEG衍生物组和灯盏乙素PEG衍生物配伍冰片组,均以等剂量灯盏乙素注射给药,观察各组对脑缺血大鼠神经功能、脑梗死体积的影响。结果模型组大鼠神经功能缺损严重,而给药组神经功能得到有效的保护;在所有给药组中,灯盏乙素PEG衍生物配伍冰片组对实验性脑缺血组织的保护作用最优,其脑梗死体积为10.28%。结论灯盏乙素PEG衍生物配伍冰片对大鼠实验性脑缺血的防治作用优于灯盏乙素及灯盏乙素PEG衍生物。
Objective To study the effects action of scutellarin, PEGylated scutellarin and PEGylated scutellarin combined with borneol on experimental cerebral ischemia in rats. Methods The model of focal cerebral ischemia/reperfusion injury was established by middle cerebral artery oecluslon （MCAO）. The rat models of experimental cerebral ischemia were then randomly divided into sham operation group, model group, scutellarin group, PEGylated seutellarin group, and PEGylated scutellarin combined with borneol group. The Medicine groups were treated with isodose of scutellarin by intravenous injection. Cerebral infarction volume and neurological function of the focal ischemia reperfusion model in rats of each group were observed. Results The severity of neurological deficit in the model group was observed, while more effective protection of neurological function could be achieved in medicine groups. The protective effects of PEGylated scutellarin combined with borneol on brain tissue induced by experimental cerebral ischemia was better than other medicine groups, and the volume of cerebral infarction was 10.28 %. Conclusions The study showed that the protective effects of PEGylated scutellarin combined with borneol on experimental cerebral ischemia in rats was better than scutellarin and PEGylated scutellarin.
出处
《实用临床医药杂志》
CAS
2010年第10期6-8,共3页
Journal of Clinical Medicine in Practice
