摘要
目的探讨通过预肌肉注射地佐辛用于妇科腹腔镜手术超前镇痛的效果及安全性.方法 ASAI^II级择期妇科腹腔镜手术患者60例,随机分为治疗组和对照组各30例,对照组缝皮前不用任何镇痛药,治疗组缝皮前30 min肌肉注射地佐辛5 mg,分别于术后1 h(T1)、4 h(T2)、8 h(T3)对切口疼痛采用VAS、BCS评分标准评分,当患者评分为VAS为10,BCS为0级时给予哌替啶100 mg肌肉内注射镇痛,记录两组患者术后使用哌替啶的时间、例数及次数,咽喉疼痛发生率等不良反应.结果治疗组术后1、4、8 h疼痛评分均低于对照组(P<0.01),术后使用哌替啶的时间、例数及次数均低于对照组(P<0.05),治疗组和对照组咽喉疼痛发生率分别为15%和60%(P<0.05),两组的不良反应除恶心呕吐外差异无统计学意义(P>0.05).结论地佐辛超前镇痛用于妇科腹腔镜手术,能有效缓解术后切口疼痛、减轻炎症反应,减少术后镇痛药的使用和不良反应,且术后苏醒迅速安全.
Objective To study the effecti and safety of preemptive analgesia with pholcodine in gynaecological laparoscopic surgery through intramuscular injection.Methods Sixty female adult patients（the ASAⅠ-Ⅱ）who underwent the gynaecological laparoscopic surgery were randomly divided into two groups：the pholcodine group and control group,30 cases in each group.Patients in the control group were not given any analgesics before suture.Patients in pholcodine group were given 5mg pholocodine through intramuscular injection before suture,the interval was 30 minutes.After operation,the pain of incision was assessed by VAS and BCS scores at 1h（T1）,4 h（T2）and 8 h（T3）respectively.When the VAS scores reached 10 and the BCS score was 0,patients were given intramuscular administration of 100mg meperidine to relieve the pain.The use time and intervals of meperidine,the cases of using meperidine,and the incidence of sore throat in patients were recorded.Results The VAS and BCS scores of patients at 1 h,4 h and 8 h after operation respectively in pholocodine group was lower than those in control group（P〈0.05）.The use time and intervals of meperidine,and the cases of using meperidine in pholocodine group was lower than those in control group（P〈0.05）.The incidence of sore throat is lower in pholocodine group than in control group（15% vs 60%,P〈0.05）,while there was no significant difference in the incidence of nausea and vomiting between two groups.Conclusion Preemptive analgesia with pholcodine can alleviate the postoperative pain and inflammatory response in gynaecological laparoscopic surgery,it also can reduce the use of analgesics and adverse reactions,and has the advantages of safety and quick palinesthesia after operation.
出处
《昆明医学院学报》
2010年第10期57-60,共4页
Journal of Kunming Medical College
关键词
地佐辛
超前镇痛
妇科腹腔镜手术
Pholcodine
Preemptive analgesia
Gynaecological laparoscopic surgery
