摘要
目的研究质子泵抑制剂(PPI)是否为危重患者发生医院获得性肺炎的危险因素。方法收集2002年6月-2009年6月收治的198例重症患者资料,分为使用PPI组(96例)和未使用PPI组(102例)。采用logistic回归分析PPI使用情况和医院获得性肺炎的关系。结果使用PPI组肺炎的发生率较高(26.9%),尤其是PPI使用时间超过7d者(37.5%)。在不同的多变量logistic回归模型中,分别用APACHEⅡ评分和入住重症监护室原因校正后,使用PPI以及使用天数均是医院获得性肺炎发生的危险因素(P=0.031,OR=2.230,95%CI:1.957～2.947;P=0.002,OR=1.824,95%CI:1.457～2.242)。结论长时间应用PPI可能是增加ICU患者发生医院获得性肺炎的一种风险因素。
Objective To identify whether proton pump inhibitors（PPI）is a risk factor of hospital-acquired pneumonia（HAP）in critical patients.Methods The clinical data of the critical patients admitted to ICU from June 2002to June 2009were retrospectively analyzed.A total of 198patients were divided into two groups：96in PPI group and 102in non-PPI group.The relationship between PPI and HAP was analyzed by logistic regression.Results The patients in PPI group had a higher risk of HAP（26.9%）,especially who were treated with PPI more than 7days（37.5%）.Adjusted by APACHEⅡscore and reason for admission to ICU,PPI therapy and the using duration of PPI were both the risk factors of HAP in different multiple logistic models（P=0.031,OR=2.230,95%CI：1.9572.947;P=0.002,OR=1.824,95%CI：1.457-2.242）.Conclusion Long-term use of PPI is a risk factor of HAP.
出处
《华西医学》
CAS
2010年第10期1811-1812,共2页
West China Medical Journal
关键词
质子泵抑制剂
危重症患者
医院获得性肺炎
Proton pump inhibitors
Critical patient
Hospital-acquired pneumonia
