摘要
目的:制备以魔芋胶为主要控释材料的结肠定位酶解型脉冲胶囊给药系统,并对其体外释药行为进行评价。方法:用灌注法制备非渗透性胶囊体,粉末直接压片法压制柱塞片,湿法制粒压片法制备含药速释片,将速释片用柱塞片密封于非渗透性胶囊体内制备脉冲胶囊,用释放度测定法考察影响释药时滞的各种因素。结果:药物的脉冲释放受含药片处方影响,柱塞片处方组成能显著影响脉冲胶囊的释药时滞,随柱塞片中魔芋胶比例增加及乳糖比例减少,羟丙甲纤维素黏度增加,释药时滞明显延长。结论:调节柱塞片处方组成可获得具有适当释药时滞的脉冲胶囊,以达到结肠定位释药的目的。
Objective： To develop a colon position pulsatile capsule drug delivery system of which the lag-time is controlled by a plug tablet mainly made of konjac glucomannan and evaluate its release profile in vitro.Method： Impermeable capsule body was prepared by filling method,the plug tablet was pressed by direct compression,and the rapid-disintegrable drug tablets was made by wet granulation.The pulsatile capsules were prepared by putting the drug tablet into the impermeable body and sealed it with the plug tablet.The factors affecting the lag-time were investigated by dissolution testing.Result： The formulation of the rapid-disintegrable drug tablets influenced the pulsatile release of the drug,the composition of the plug tablet significantly influenced the lag-time;the lag-time was extended with the higher viscosity of HPMC and the increased proportion of konjac glucomannan.Conclusion： The pulsatile capsule with a suitable lag-time and colon position characteristics can be achieved by adjusting the composition of the plug tablet.
出处
《中国中药杂志》
CAS
CSCD
北大核心
2010年第23期3127-3130,共4页
China Journal of Chinese Materia Medica
基金
重庆医科大学校办课题项目(XBYB2007098)
关键词
魔芋胶
脉冲胶囊
结肠定位
酶解型
konjac glucomannan
pulsatile capsule
colon-specific delivery
enzymatic degradation
