摘要
纳米羟基磷灰石(n-HAP)独特的表面晶体结构可使其对药物产生选择性吸附,而不同的孔结构则可有效控制载药量和释药速率,同时,良好的生物活性使其在骨疾病治疗过程中显示着重要的骨诱导作用。分析讨论了n-HAP作为药物载体材料的研究现状及工艺技术,探讨了其与高分子材料复合后对药物缓释性能的影响,指出了n-HAP粒子作为药物载体的发展趋势及存在的主要问题。
The different crystal surface structure of nano-hydroxyapatite（n-HAP） lead to Selective adsorption on the drug, and its different pore structure can effectively control the release rate of drug loading. At the same time, due to the good biological activity, nano-hydroxyapatite shows an important osteoinduction effect in the course of bone disease treatment. The related research and technology of n-HAP as a drug carrier, the improvement of drug delivery after its combination with the polymer are discussed, and the major trends and problems of n-HAP as drug carriers are pointed out. Key words drug carrier, nano-hydroxyapatite, surface adsorption, pore structure, composite
出处
《材料导报》
EI
CAS
CSCD
北大核心
2010年第23期116-120,共5页
Materials Reports
基金
国家自然科学基金(50572072)
关键词
药物载体
纳米羟基磷灰石
表面吸附
孔结构
复合
drug carrier, nano-hydroxyapatite, surface adsorption, pore structure, composite
