摘要
目的 探讨非小细胞肺癌的骨转移规律和影响因素。方法 对638例非小细胞肺癌患者的骨转移情况进行统计分析。结果 非小细胞肺癌骨转移率为35.3%。多发转移者201例,全组平均病灶3.4个。骨转移的部位以胸部最常见,其它依次为脊柱、骨盆、肢体和颅骨,各组间比较有非常显著差异(P<0.005)。腺癌和腺鳞癌骨转移率明显高于鳞癌(P<0.005)。细胞分化程度较低者骨转移率明显增高(P<0.005)。Ⅲ～Ⅳ期骨转移率明显高于Ⅰ～Ⅱ期(P<0.005)。结论 肺癌骨转移临床常见,肺癌患者应常规作全身骨显像检查。
Objective To study the pattern of skeletal metastasis in non small cell lung cancer and its associated factors. Methods Six hundreds and thirty eight patients with non small cell lung cancer pathologically proved were retrospectively reviewed. Results The percentage of skeletal metastasis was 35.3% in 638 cases. Multiple metastasis accounted for 201 cases. The sites of metastatic lesions for each patient was 3.4. There was highly significant difference in different site of skeletal metastasis, for instance, thorax, spine, pelvis, limbs and skull in order of incidence (P<0.005). Bone metastasis rate of adenocarcinoma and adenosquamous carcinoma groups was remarkably higher than that of squamous cell carcinoma (P<0.005), which was highly significant higher in stage Ⅲ～Ⅳ than that in stage Ⅰ～Ⅱ(P<0.005). The rate in patients with lower differentiated lung cancer was also highly significant higher than those with well differentiated cancer (P<0.005).Conclusion Skeletal metastasis is frequent in patients with lung cancer. Bone imaging should be performed routinely in all lung cancer patients, and it is helpful to estimate the stage and to make the therapeutic arrangement of lung cancer.
关键词
肺癌
骨转移瘤
影响因素
Lung cancer Skeletal metastasis Prognosis
