摘要
目的：观察大承气汤对兔内毒素休克血清溶菌酶活性的影响。方法：血清溶菌酶活性的测定采用分光光度法，测定波长为５２０ｎｍ。结果：静脉注射大肠杆菌毒素（４０μｇ／Ｋｇ）的家兔血清溶菌酶活性较生理盐水对照组明显升高（Ｐ＜０．０１）。经大承气汤（１０ｍｌ／ｋｇ）口服给药预防３ｄ，治疗２ｄ的家免，血清溶菌酶活性较内毒素模型组明显降低（Ｐ＜０．０５），而接近正常水平。结论：大承气汤通过其消炎、抗菌。
Objective:To study the effect of Da Cheng Qi Tang(DCQT) on serum lysozyme activity in rabbits.Methods:Spectrophotometry was used to determine the serum lysozyme activity.Results:The serum lysozyme activity was obviously elevated (P<0.01) after injecting intravenously Escherichia coli endotoxin(40 μg/kg) into the rabbits compared with that of saline group.In the group of DCQT,the rabbits were pretreated by oral DCQT(10 g/kg) for 3 days.Having been injected E coli endotoxin,they were continuously treated with DCQT for 2 more days.Compared to the model group the serum lysozyme level significantly decreased (P<0.05) to a level which was nearly normal.Conclusion:DCQT could recover the serum lysozyme activity to normal level through reducing inflammation,resisting bacteria,inhibiting absorption of endotoxin and stabilizing the cell membrance.
出处
《中国中西医结合外科杂志》
CAS
1999年第2期81-82,共2页
Chinese Journal of Surgery of Integrated Traditional and Western Medicine
