摘要
目的探讨皮肤鳞状细胞癌(SCC)的临床、病理学特征、恶性程度及预后。方法收集42例皮肤鳞状细胞癌,分析其临床和组织病理学特征,并通过免疫组化方法分析其p16、pRb蛋白的表达。结果本病的典型皮损为不规则斑块或结节,中央可有溃疡或菜花状增生;组织病理以鳞状细胞向下增生,突破基底膜并侵入真皮或皮下组织为特征。p16蛋白阳性表达低于对照组(P<0.05),pRb蛋白则高于对照组(P<0.05)。结论皮肤鳞状细胞癌具有特殊的临床及组织病理特点,免疫组化有助于判断其发病、恶性程度及预后。
Objective To study the clinical and pathological features,malignancy and prognosis of cutaneous squamous cell carcinoma（SCC）.Methods 42 patients with SCC were collected,and their clinical features were analyzed with pathological aspects observed by immunohistochemical SP techniques.Results Clinically,SCC of most commonly consists of a shallow ulcer surrounded by a wide,elevated,indurated border.Often the ulcer is covered by a crust that conceals a red,granular base.On histologic examination,one finds the tumor to consist of irregular masses of epidermal cells that proliferate downward into the dermis.The Broders′ classification depends on the differentiation of squamous cells.The expression levels of p16 was lower than controls（P〈0.05）,whereas pRb was higher than controls（P〈0.05）.Conclusion SCC is a common skin malignant tumor with it′s typical clinical and pathological features.The diagnosis,malignancy and prognosis of SCC can be confirmed by immunohistochemical staining.
出处
《重庆医学》
CAS
CSCD
北大核心
2010年第23期3217-3218,3220,共3页
Chongqing medicine
