摘要
【目的】探讨热疗与化疗结合在卵巢恶性肿瘤治疗中的作用。【方法】采用热化疗治疗２２例术后有残余肿块的卵巢恶性肿瘤患者（实验组），与同期１２例常规化疗病人（对照组）进行比较。使用ＶＨＲ－９１５ＭＶ热疗机，手术中将带有导管的探头置于肿块下，当温度达到４１℃或较加温前上升３℃以上时继续保持４０ｍｉｎ。同时采用以顺铂为主的全身及腹腔双途径化疗，共计２～４疗程。【结果】２～３疗程后实验组完全缓解率（ＣＲ）４５．４％，部分缓解率（ＰＲ）２２．７％，有效率６８．１％。对照组ＣＲ率８３％，ＰＲ率２５％，有效率３３．３％，低于实验组。实验组有６例获得再次手术机会，其中２例术后病理证实达到临床及病理ＣＲ。该疗法无明显不良反应。【结论】热疗作一种辅助治疗与化疗有协同作用，可望提高晚期卵巢恶性肿瘤的治愈率。
To explore the
therapeutic effects of chemotherapy combinig with hyperthermia on malignant ovarian tumors. A
comparison of therapeutic effects between 22 patients carrying residual tumors treated with
thermochemotherapy (study group)and 12 patients treated with routine chemotherapy
alone(control group) was performed.Using UHR-915 MV thermotherapy machine effective heat
could penetrate a depth of 12 cm.During operation a probe with catheter was put under the
cancer mass.When temperature reached 41 or rose 3 above that before heating,40 min was
maintained.At the same period cis-diaminodichloroplatinum(DDP)-based regimen used as
systemic and intraperitoneal chemotherapy was added and totally 24 courses were given. After
23 courses of thermochemotherapy, the overall response rate was 682% with a complete
remission rate (CR)of 45.4% and partial CR rate (PR) of 22.7%.The former two percentages were
higher than 33.3% and 8.3% of the control group(its PR was 25%),respectively.Furthermore,6
patients in st udy group got the opportunity of second operation,clinical and pathological CR
were obtained in 2 of them.Toxicity and side effects were not beyond tolerance. As a adjuvant
method,hypP2erthermia combining with chemotherapy can result in
synergism.Thermochemotherapy can improve the therapeutic effects for advanced malignant
ovarian tumors and deserve further trial.
出处
《湖南医学》
1999年第3期169-170,共2页
Hunan Medical Journal
关键词
卵巢肿瘤
药物疗法
热化疗
ovarian neoplasms
cancer
drug
therapy
hyperthermia,induced
