摘要
目的应用Meta分析评价肿瘤坏死因子(TNF)-α-238位点多态性与胃癌易感性的关系。方法通过计算机检索PubMed和中文期刊网(CNKI)数据库,收集2000～2009年国内外公开发表的关于肿瘤坏死因子TNF-α基因多态性与胃癌的关系研究的文献。应用RevMan5.0软件进行统计学分析,二分类变量用比值比(OR)为效应量,并计算95%CI。根据异质性检验,分别应用固定效应模型或随机效应模型进行分析处理。结果对于TNF-α-238位点,研究中共纳入10篇文献,病例组共1 623人,对照组共有3 420人,经异质性检验,各研究间有统计学异质性(P=0.03),采用随机效应模型进行分析,结果显示TNF-α-238位点等位基因的分布在2组中比较差异无统计学意义(P=0.23)。在地区的基础上进行亚组分析显示:在西方人群中病例组和对照组分析差异无统计学意义(P=0.74);在东亚人群中病例组和对照组该位点差异有统计学意义(P=0.04,OR=1.42,95%CI=1.02-1.98)。结论在东亚人群中TNF-α-238位点多态可能是增加胃癌患病风险的危险因素。
Objective We conducted a meta-analysis to assess the association between tumor necrosis factor-α（TNF-α） gene-238（G/A）polymorphism and gastric cancer（GC）.Methods We searched the reference from PubMed and CNKI databases between 2001-2010 published for the association between the TNF-α gene polymorphism and gastric cancer（GC） susceptibility.The Revman 5.0 software was used for meta-analysis.Dichotomous outcomes were expressed as odds ratios（OR） with 95% confidence intervals（CI）.According to the result of the the heterogeneity test,we used the fixed effect model or rondom effect model to carry on the merge analysis respectively.Results There were 1623 GC patients and 3420 controls for TNF-α-238,Overall,allele contrast（A vs.G） of TNF-α-238 polymorphism didn＇t produce significant results in worldwide populations（Pheterogeneity=0.03,P=0.23）.We also performed subgroup analyses based on ethnicity（west,east Asian）.No significant association was observed in west subgroup analysis（P=0.74）.Significant association was observed in east Asians subgroup analysis（P=0.04,OR=1.42,95CI=1.02-1.98）.Conclusions The polymorphism of the TNF-α-238 locus would be a risk factor for GC especially in east Asians.
出处
《新疆医科大学学报》
CAS
2010年第11期1350-1353,1357,共5页
Journal of Xinjiang Medical University
关键词
TNF-Α
基因多态性
胃癌
META分析
Tumor necrosis factor-alpha
Gastric cancer
Polymorphism
Meta-analysis
