摘要
采用三聚磷酸钠(TPP)和六偏磷酸钠(SHMP)为复合交联剂,制备了离子交联网络结构的壳聚糖水凝胶微球。分析讨论了交联剂质量配比、pH以及离子强度等对壳聚糖微球溶胀性能的影响。结果表明:使用复合交联剂制备的微球的溶胀度比单独使用TPP或SHMP的分别低62.4%和41.3%,交联效率得到明显提高;当m(TPP)∶m(SHMP)=3∶5,交联剂pH=5时,制备的微球交联程度最好,结构最密实;在pH=1.2的缓冲溶液中,溶胀度可达到357%,而且凝胶没有任何破碎。微球具有较好的离子强度和pH敏感性,在酸性介质中有较高的溶胀度。
Chitosan gel beads were prepared using sodium tripolyphosphate（TPP） and sodium hexametaphosphate（SHMP） composite as cross-linking agents.The influence of mass ratio of cross-linking agents,pH value and ionic strength on swelling properties of chitosan gel beads are discussed.According to the（results,） composite cross-linking agent can decrease the swelling degree by 62.4% and 41.3% in comparison with TPP or SHMP alone,respectively,and increase the ionic-crosslinking efficiency.The most compact chitosan beads can be obtained when m（TPP）∶m（SHMP）=3∶5 and pH=5.The swelling degree can reach up to 357% when cured in pH=1.2 buffer solution.The beads have good ionic strength and pH sensitivity and high swelling degree in acidic media.
出处
《功能高分子学报》
CAS
CSCD
北大核心
2010年第4期396-399,共4页
Journal of Functional Polymers
关键词
壳聚糖
六偏磷酸钠
三聚磷酸钠
水凝胶微球
溶胀
chitosan
sodium tripolyphosphate
sodium hexametaphosphate
beads
swelling
