摘要
目的比较3组方案治疗肝硬化上消化道出血(UGH)的临床疗效及安全性。方法将146例肝硬化上消化道出血患者在常规治疗基础上随机分为3组,分别使用不同的治疗方案。Ⅰ组(52例)以生长抑素0.25mg静注后,继之0.25mg/h持续点滴;Ⅱ组(49例)以垂体后叶素10u静注后,继以0.2～0.4u/min加硝酸甘油20～50μg/min持续静滴;Ⅲ组(45例)以垂体后叶素10u静注后,继以0.2～0.4u/min持续静滴。止血后剂量减半,继续用药48h,比较其临床疗效及不良反应。结果Ⅰ、Ⅱ组止血时间均短于Ⅲ组(P<0.05,P<0.01)。Ⅰ、Ⅱ组间差异也有统计学意义(P<0.05);Ⅰ、Ⅱ、Ⅲ组显效率分别为48.1%、38.8%和26.7%,总有效率分别为82.7%、69.4%和51.1%,Ⅰ组显效率高于Ⅲ组(P<0.05),Ⅰ、Ⅱ组总有效率均高于Ⅲ组(P<0.05,P<0.01),Ⅰ、Ⅱ组间显效率和总有效率差异均无统计学意义(P>0.05)。Ⅲ组不良反应均高于Ⅰ、Ⅱ组,Ⅰ、Ⅱ组间差异无统计学意义(P>0.05)。结论Ⅰ、Ⅱ组方案治疗肝硬化UGH有良好的疗效和安全性,可根据患者具体情况灵活选用。
Objective To compare the therapeutic effect and safety of three projects on upper gastrointestinal hemorrhage（UGH） caused by hepatocirrhosis.Methods 146 patients with UGH caused by hepatocirrhosis were randomly divided into three groups.Group Ⅰ（n=52） were given somafostatin 0.25 mg intravanous injection,followed by continuous intravanous drip at a rate of 0.25 mg/h.GroupⅡ（n=49） were given pituitrin 10 u intravanous injuection,followed by continuous intravanous drip at a rate of 0.2～0.4 u/min pituitrin and 20～50 μg/min nitroglycerin.Group Ⅲ（n=45） were given pituitrin 10 u intravanous injection,followed by continuous intravanous drip at a rate of 0.2～0.4 u/min.As soon as bleeding stopped,the doses dropped to a half and used continuously for 48 hours,their clinical efficacy and adverse reactions were compared.Results The bleeding-controled time of group Ⅰ and Ⅱ were shorter than that of group Ⅲ（P0.05,P0.01）,there was also significant different between group Ⅰ and Ⅱ（P0.05）.The remarkable effectual rate of group Ⅰ,Ⅱand Ⅲwere 48.1%,38.8% and 26.7%respectively,the total effective rate of them were 82.7%,69.4% and 51.1% respectively,the remarkable effectual rate of group Ⅰ was higher than that of group Ⅲ（P0.05）,the total effective rate of group Ⅰ and Ⅱ were higher than that of group Ⅲ resepectively（P0.05,P0.01）,there was no significant different in the remarkable effectual rate and the total effective rate between group Ⅰ and Ⅱ（P0.05）.The adverse events of group Ⅲ were more than those of group Ⅰ and Ⅱ,there was no different in the radverse events between group Ⅰ and Ⅱ（P0.05）.Conclusion Group Ⅰ and Ⅱ projects have good clinical efficacy and safe in treament of UGH caused by hepatocirrhosis,which can be chosen according to concrete conditions of patients.
出处
《临床消化病杂志》
2010年第6期335-337,共3页
Chinese Journal of Clinical Gastroenterology
关键词
治疗方案
肝硬化
上消化道出血
疗效
Therapeutic schedule
Hepatocirrhosis
Upper gastrointestinal hemorrhage
Effect
