期刊文献+

脑靶向给药技术的研究现状 被引量:3

在线阅读 下载PDF
导出
摘要 从20世纪末到21世纪初,神经科学有了突飞猛进的发展。新技术的使用促进了人们对大脑的了解并为治疗精神和神经疾病提供了新方法。从药剂学角度来说,脑靶向给药技术越来越受到重视。与全身用药相比,脑靶向给药技术难度大,但同时具有治疗效果好、用药量小、
作者 张兆芹
机构地区 [
出处 《实用医药杂志》 2010年第12期1129-1132,共4页 Practical Journal of Medicine & Pharmacy
  • 相关文献

参考文献20

  • 1Zlokovic BV.The blood-brain barrier in health and chronic neurodegenerative disorders.Neuron,2008,57(2):178-201.
  • 2Boado RJ.Blood-brain barrier transport of non-viral gene and RNAi therapeutics.Pharm Res,2007,24(9):1772-1787.
  • 3Boado RJ.A new generation of neurobiological drugs,engineered to overcome the challenges of brain drug delievery.Drug News Perspect,2008,21(9):489-503.
  • 4Murugesan V,Parbhakar YS,Katti SB.CoMFA and CoMSIA studies on thiazolidin-4-ones as anti-HIV-agents.J Mol Graph Model,2009,27(6):735-743.
  • 5Allen DD,Geldenhuys WJ.Molecular modeling of blood-brain harrier nutrient transporters:in silico basis for evaluation of potential drug delievery to the central nervous system.Life Sci,2006,78(10):1029-1033.
  • 6Pavan B,Dalpiaz A,Ciliberti N,et al.Progress in drug delievery to the central nervous system by the prodrug approach.Molecules,2008,13(5):1035-65.
  • 7Gynther M,Laine K,Ropponen J,et al.Large neutral amino acid transporter enables brain drug delievery via prodrugs.J Med Chem,2008,51 (4):932-936.
  • 8Juillerat-Jeanneret L.The targeted delivery of cancer drugs across the blood-brain barrier,chemical modifications of drugs or drugnsnoparticles? Drug Discov Teday,2008,13(23-24):1099-106.
  • 9Chen P,Bodor N,Wu WM,Prokai L.Strategies to target kyotorphin analogues to the brain.J Med Chem,1998,41(20):3773-81.
  • 10Ohtsuki S.New aspects of the blood-brain barrier transporters:its physiological roles in the central nervous system.Biol Pharm Bull,2004,27(10):1489-96.

同被引文献34

引证文献3

二级引证文献4

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部