摘要
用放射配基竞争结合法和放射免疫法测定连续激发哮喘的大鼠第１，３，７天肺组织β受体（βＡＲ）和环磷酸酰苷（ｃＡＭＰ）水平。结果：哮喘大鼠肺组织βＡＲ和ｃＡＭＰ含量于激发后逐日下降，激发第３天，βＡＲ含量已明显低于正常对照组（Ｐ＜０．０１），第７天时，βＡＲ和ｃＡＭＰ均降至最低点，与正常对照组相比，差异极显著（Ｐ＜０．０１），小青龙汤和补肾定喘汤治疗后，βＡＲ、ｃＡＭＰ含量显著上升（Ｐ＜０．０１），其中βＡＲ含量仍低于正常对照组（Ｐ＜０．０１），小青龙汤组ｃＡＭＰ含量已达到正常水平。
The first, third and seventh day pulmonary tissue accepter and cAMP levels of consecutive asthma attacks of rats have been determined by the methods of the radio aglucone comptition combination and the radioimmunoassay (RIA). As a result, after attacking, the pulmonary tissue βAR and cAMP levels of rats with asthma decreased gradually. In the third day, the βAR level had been greatly lower than that of the normal control group( p <0.01). And in the seventh day, βAR and cAMP levels all went down almost to the minimal levels. As compared with that of the normal control group there was extremely significant difference observed between two groups( p <0.01). After the rats with asthma were treated with Minor Green Blue Dragon Decoction and Bushendingchuan Decoction, the βAR and cAMP levels increased greatly( p <0.01). But the βAR level was still lower than that of the normal control group( p <0.01), and the cAMP level had reached the normal level. It was suggested that Minor Green Blue Dragon Decoction and Bushendingchuan Decoction possess the action of increasing the pulmonary tissue βAR and cAMP levels of rats with asthma.
出处
《中成药》
CAS
CSCD
1999年第6期304-306,共3页
Chinese Traditional Patent Medicine
关键词
大鼠
哮喘
环磷酸腺苷
βAR
中医药疗法
Minor Green Blue Dragon Decoction, Bushendingchuan Decoction, rat asthma model, βAR, cAMP
