摘要
目的:介绍各种骨组织工程支架的特性及在修复骨缺损中的作用。方法:以"骨组织工程,支架材料,骨缺损"为中文关键词;以:"bone tissue engineering,scafold,bone defect"为英文关键词,采用计算机检索2000-01/2010-06相关文章。纳入骨组织工程支架修复骨缺损相关的文章。选择28篇文献重点介绍各种骨组织工程支架的特性及在修复骨缺损中的特点。并应用硫酸钙人工骨进行验证。结果:用于骨组织工程的支架材料众多,目前,骨组织工程支架材料主要分为3类:生物衍生材料、无机材料和高分子材料,每种材料在修复骨缺损中都有各自的优缺点。随着研究的不断深入,复合支架材料成为目前的研究热点之一。一些具有生物活性的无机材料,如生物玻璃、羟基磷灰石已经被用来加入到胶原、壳聚糖的基体中来制备新型的骨组织工程复合支架材料。至今还未研制出一种理想的适于骨组织工程的支架材料。临床验证显示硫酸钙人工骨修复大块骨缺损效果较好。结论:相信随着各学科的发展,骨组织工程用支架材料的性能会越来越完善,从而促进骨组织工程的发展,最终应用于临床。
OBJECTIVE：To introduce the characteristics of various bone tissue engineering scaffolds and their role in repairing bone defects.METHODS：Using ＂bone tissue engineering,scaffold,bone defect＂ in Chinese and in English as the Keywords,a computer search of articles from January 2000 to June 2010 was performed.Articles related to bone tissue engineering scaffolds to repair bone defects were included.Totally 28 articles focuses on the characteristics of various bone tissue engineering scaffolds in repairing bone defects,and verified using calcium sulfate artificial bone.RESULTS：There are many materials for bone tissue engineering scaffolds,at present,the scaffold materials can be divided into three categories：bio-derived materials,inorganic materials and polymer materials.Each material has its own advantages and disadvantages in the repair of bone defects.With the deepening of the study,a composite scaffold becomes the current research focus.Some bioactive inorganic materials,such as bioactive glass and hydroxyapatite,have been used to prepare novel composite scaffold for bone tissue engineering by adding to collagen and chitosan matrix.Until now,there has no ideal scaffold for bone tissue engineering.Clinical verification shows that calciums sulfate artificial bone is effective in repairing large bone defects.CONCLUSION：It is believed that with the development of various disciplines,the properties of bone tissue engineering scaffold materials will be more perfect,thereby promoting the development of bone tissue engineering,and ultimately apply for clinical application.
出处
《中国组织工程研究与临床康复》
CAS
CSCD
北大核心
2010年第47期8869-8872,共4页
Journal of Clinical Rehabilitative Tissue Engineering Research
