摘要
目的:制备一种新型脉冲式胶囊给药系统,探索影响药物在一定的时滞后脉冲释放的因素。方法:以蘸胶工艺制备不溶性半透膜囊体,灌装药物粉末或药物与渗透促进剂混合物,以果胶直接压片制备胶塞,塞入囊体后,套上胃溶性囊帽和囊体后外包肠溶衣,进行体外释放试验。结果:该给药系统在人工胃液中不变形,药物不释放,在pH7.4人工肠液中药物的脉冲释放受肠溶包衣厚度、不溶性囊体中致孔剂含量和填充物渗透促进剂比例的影响。结论:胶囊系统设计原理简单,各组成部分可单独制备,药物释放可根据要求来设计调节,可应用于多种药物,有望开发成一种新型药物脉冲释放系统。
OBJECTIVE To develop a new pulsatile release capsule drug delivery system and explore the factors influening the drug pulsed release of the system at the desired time.METHODS The insoluble semipermeable capsule body was prepared by dipping-drying process and filling the body with drug powder or mixture of drug and osmotic additives.The stopper was made through compressing the pectin powder,and stuffed the body.The insoluble body was capped into a stomach-soluble capsule,followed with the enteric coating outside the capsule.Then in vitro release was investigated.RESULTS The system was not deformed in artificial gastric fluid and the drug was not released.The pulsatile release in the artificial intestinal fluid(pH 7.4) was affected by the thickness of enteric coating,pore formers content of insoluble capsule body and the ratio of osmotic additives.CONCLUSION The mechanism of this pulsatile release capsule is simple,and the components can be prepared individually.The drug release can be desired as required,and the system suit to a variety of drugs.The pulsatile release capsule is expected to be a new type of drug pulse delivery system.
出处
《中国医院药学杂志》
CAS
CSCD
北大核心
2011年第3期203-207,共5页
Chinese Journal of Hospital Pharmacy
关键词
脉冲释药
胶囊
盐酸维拉帕米
pulsatile drug delivery system
capsule
verapamil hydrochloride
