摘要
目的 研究经肠补充谷氨酰胺（ Ｇｌｎ） 对胃肠手术患者血浆Ｇｌｎ ，还原型谷胱甘肽（ＧＳＨ） 和丙二醛（ ＭＤＡ） 水平的影响．方法 将２０ 例胃肠手术患者随机分为Ｇｌｎ 组（ 术后经肠补充Ｇｌｎ） 和ＮｏｎＧｌｎ 组（ 不补充Ｇｌｎ） ，观察术后血浆Ｇｌｎ ，ＧＳＨ 和ＭＤＡ 水平的变化．结果 术后ｄ １ 两组血浆Ｇｌｎ ，ＧＳＨ 浓度明显下降，ＭＤＡ 含量明显增加，ｄ ６ Ｇｌｎ 组上述指标基本恢复至术前水平，但ＮｏｎＧｌｎ组Ｇｌｎ 和ＧＳＨ 的降低以及ＭＤＡ 的升高仍较明显．结论 经肠补充Ｇｌｎ 能有效维持术后血浆ＧＳＨ 的正常水平，减轻术后机体的脂质过氧化反应．
AIM To investigate the effect of glutamine supplementation on plasma levels of glutamine (Gln), reduced glutathione (GSH) and malondialdehyde (MDA) in gastrointestinal surgical patients. METHODS Twenty patients were randomized to two groups (Gln group and Non Gln group), fed enterally with or without glutamine (0 3*!g·kg -1 ·d -1 ) supplementation. The changes of Gln, GSH and MDA in plasma were measured before and after surgical trauma. RESULTS The plasma Gln and GSH levels decreased and the MDA levels increased significantly in two groups 1 day postoperatively. On the 6th day, the Gln, GSH and MDA approached to the preoperative levels in the Gln group. But the decrease of GSH and the increase of MDA remained obvious compared to the preoperative levels in the Non Gln group. CONCLUSION Enteral glutamine administration can preserve GSH levels and lessen damage effect of lipid superoxidation after surgical trauma.
出处
《世界华人消化杂志》
CAS
1999年第10期867-868,共2页
World Chinese Journal of Digestology
关键词
胃溃疡
谷氨酰胺
谷胱甘肽
外科手术
stomach ulcer/surgery
duodenal ulcer/surgery
glutamine
glutathione/blood
malondialdehyde/blood
