摘要
目的和方法 为探讨蛛网膜下腔出血（ＳＡＨ）不同时期血与脑脊液中一氧化氮（ＮＯ）含量变化的临床意义；送检１４ 例ＳＡＨ 不同时期血清与脑脊液，采用Ｇｒｅｅｎ 改良法检测ＮＯ含量，并配有３０ 例血清的正常对照。结果 ＳＡＨ 血清中ＮＯ均较对照组低，尤以第２ 周为著；脑脊液中ＮＯ含量第２ 周最低，第３ 周含量高于第１周；ＳＡＨ的出血量多少与血和脑脊液中ＮＯ含量呈负相关。结论 ＳＡＨ 的ＮＯ的含量变化说明。
Objective In order to study the significance of assaying Nitric Oxide content of serum and cerebral spinal fluid in different period of subarachnoid hemorrhage.Methods An improved method of Green was used to measure NO content in the serum and cerebral spinal fluid of subarachnoid hemorrhage of 14 cases, While 30 of healthy subjects were tested as the control group. Result The result showed that the activity of NO in the serum decreased in different periods. NO content in the cerebral spinal fluid at 7 14 d was the lowest. The various degrees of subarachnoid hemorrhage were negatively correlated with NO contents in the serum and cerebral spinal fluid. Conclusions NO is involved in pathophysiology of subarachnoid hemorrhage. Decrease of NO content was one of the causes of cerebral vasospasm, which might serve as the basis for subarachnoid hemorrhage.
出处
《中国神经免疫学和神经病学杂志》
CAS
1999年第3期179-182,共4页
Chinese Journal of Neuroimmunology and Neurology
关键词
一氧化氮
蛛网膜下腔出血
脑脊液
nitric oxide
subarachnoid hemorrhage
cerebral vasospasm
haemoglobin
