摘要
目的：探讨脑脊液α肿瘤坏死因子（ＣＳＦＴＮＦα） 在中枢神经系统白血病（ＣＮＳＬ） 的临床意义。方法：用放射免疫法测定了４０ 例急性白血病患者ＣＳＦＴＮＦα含量。结果：ＣＮＳＬ患者ＣＳＦＴＮＦα含量全部升高，与对照组及无ＣＮＳＬ组比较有极显著性差异（ Ｐ＜ ０．０１） 。１０ 例ＣＮＳＬ患者治疗后８ 例缓解的ＣＳＦＴＮＦα含量明显下降；１ 例虽缓解但下降不明显，半月后复发。另１ 例病情恶化，ＣＳＦＴＮＦα含量反较治疗前升高。无ＣＮＳＬ组３０ 例患者７ 例ＴＮＦα增高，随访８０ ｄ ，有５ 例确诊为ＣＮＳＬ。结论：ＣＮＳＬ确诊前中枢神经系统（ＣＮＳ） 已受到白血病细胞的浸润；ＣＳＦＴＮＦα是诊断ＣＮＳＬ的敏感指标，有助于ＣＮＳＬ的早期诊断和疗效监测。
Objective:To investigate the clinical significance of tumor necrosis factor α(TNF α) in cerebrospinal fluid (CSF) in patients with central nervous system leukemia (CNSL). Methods:40 patients with acute leukemia had been involved in this study. TNF α level in CSF was detected by radioimmunoassay. Results:The cerebrospinal fluid tumor necrosis factor α (CSF TNF α) is significantly elevated in all patients with CNSL compared to those without CNSL and the normal subject (P<0.01),of the 10 patients with CNSL after treatment,8 of them remitted and the level of CSF TNF α decreased remarkable and one remitted but without the level decreasing remarkably ,and it relapsed after 15 days.The condition of the rest one become worse during the treatment,whereas,its indicator increased.TNF α level elevated in 7 out of 30 acute leukemia patients without CNSL,and 5 patients developed CNSL during the follow up for 80 days.Conclusion:The central nervous system has been invadad by leukemic cells before diagnosis of CNSL;CSF TNF α is a sensitive indicator for diagnosis of CNSL,it is of great value for early diagnosis and monitor of treatment.
出处
《中国免疫学杂志》
CAS
CSCD
北大核心
1999年第10期472-474,共3页
Chinese Journal of Immunology
关键词
脑脊液
肿瘤坏死因子Α
中枢神经系统
白血病
Cerebrospinal fluid Tumor necrosis factor α Central nervous system leukemia
