摘要
目的探讨指突状树突细胞肉瘤(interdigitating dendritic cell sarcoma,IDCS)的临床病理学特点,以提高对该病的认识。方法对1例颈部淋巴结IDCS进行组织形态学观察和免疫组织化学(组化)检测,同时复习相关文献。结果大体见标本呈灰红色结节状,体积2.0 cm×1.5 cm×1.5 cm,切面灰红,实性,质中。光学显微镜下观察淋巴结结构部分破坏,肿瘤细胞异型性明显,免疫组化染色S100、CD68阳性,Ki-67阳性细胞数10%,SMA、Desmin、CD34、EMA、CK、CD21、CD35、CD23、CD1α、CD20、CD3、HMB45、MelanA、ALK均阴性。结论 IDCS的组织形态学特点不具特征性,需加强与其他恶性肿瘤的鉴别,诊断往往依赖于免疫组化染色。
Objective To explore the clinicopathological characterristics of interdigitating dendritic cell sarcoma（IDCS）.Methods One case of IDCS of the cervical lymph node was observed under light microscope with stains of hematoxylin eosin.Immunohistochemical staining and the literature were reviewed.Results The specimen showed greyish and red node with size of 2.0 cm×1.5 cm×1.5 cm,as in moderate parenchyma.The lymph node architecture was partially destroyed.Heteromorphism of tumor cells was apparent.Tumor cells expressed S100,CD68,and 10% tumor cells Ki-67 was positive.SMA,Desmin,D34,EMA,CK,CD21,CD35,CD23,CD1α,CD20,CD3,HMB45,MelanA,ALK were all negative.Conclusion The typical morphological characteristics of IDCS are rare,and the differentiation with other malignant tumor is essencial.Immunohistochemistrical approach is necessary in diagnosis.
出处
《临床误诊误治》
2011年第1期36-38,I0001,共4页
Clinical Misdiagnosis & Mistherapy
关键词
头颈部肿瘤
指突状树突细胞肉瘤
免疫组织化学
诊断
鉴别
Head and neck neoplasms
Interdigitating dendritic cell sarcoma
Immunohistochemistry
Diagnosis
differential
