摘要
目的:考察注射用奥拉西坦与5%、10%葡萄糖注射液,0.9%氯化钠注射液和5%葡萄糖氯化钠注射液的配伍稳定性。方法:采用高效液相色谱法考察奥拉西坦配伍液在8 h内的主药含量、有关物质的变化;用紫外分光光度法测5-羟甲基糠醛含量的变化,同时测定pH值并观察溶液颜色变化和可见异物。结果:奥拉西坦在10%葡萄糖注射液中6 h含量变化不明显,8 h含量降低将近4%;其他配伍液各指标变化不明显。结论:室温条件下注射用奥拉西坦与10%葡萄糖注射液配伍6 h内稳定,与其他3种输液配伍8 h内稳定。
Objective： To study the stability of oxiracetam injection in four kinds of infusions.Methods： Oxiracetam injection was mixed with 5% and 10% glucose infusion（GS）,0.9% normal saline infusion（NS）,5% glucose in normal saline infusion（GNS）;the relative substances and the contents of principal agent were observed by HPLC;5-hydroxymethyl furfural were observed by UV,and the changes of the mixtures in appearance,visible foreign substance,pH value were observed.Results： The content of principal agent of oxiracetam in 10% GS decreased nearly 4% with in 8 h,but it had no marked change within 6 h.No marked changes were noted for the other outcome measures.Conclusion： Oxiracetam injection was compatible with the 10% GS within 6 h,and it was compatible with the other three infusions within 8 h at room temperature.
出处
《江苏大学学报（医学版）》
CAS
2011年第1期80-83,共4页
Journal of Jiangsu University：Medicine Edition
