摘要
[目的]评价转化生长因子βⅡ型受体(TβRⅡ)及Smad7在肺鳞癌组织中表达及其相关性。[方法]用Western blot法检测18例肺鳞癌癌组织及癌旁组织中TβRⅡ和Smad7的表达。[结果]TβRⅡ在癌组织的表达为癌旁组织的0.73倍(P<0.05),Smad7在癌组织表达是癌旁组织的3.6倍(P<0.05)。肺鳞癌组织Smad7和TβRⅡ表达呈负相关(r=-0.9173,P<0.05)。[结论]TβRⅡ低表达及Smad7过表达与肺鳞癌的发生密切相关。
[Purpose] To investigate the expression of transforming growth factor beta receptor Ⅱ （TβRⅡ） and Smad7 and their correlation in lung squamous cell carcinoma tissues. [Methods] The TβRⅡ and Smad7 expression of carcinoma tissues and adjacent normal tissues in 18 cases with lung squamous carcinoma was detected by Western blot. [Results] The expression levels of TβRⅡ in lung squamous carcinoma tissues were 0.73-fold with adjacent normal tissues （P0.05）. Expression levels of Smad7 in lung squamous carcinoma tissues were 3.6-fold than that in adjacent normal tissues （P0.05）. TβRⅡ expression was negatively correlated with Smad7 expression in lung squamous carcinoma tissues （r=-0.9173, P0.05）.[Conclusion] Low expression of TβRⅡ and overexpression of Smad7 may closely involve in the carcinogenesis of lung squamous carcinoma.
出处
《肿瘤学杂志》
CAS
2010年第12期926-929,共4页
Journal of Chinese Oncology
基金
重庆市卫生局课题资助项目(07-2-189)
关键词
肺肿瘤
SMAD7
转化生长因子Β受体
lung neoplasms
Smad7
transforming growth factor beta receptor Ⅱ
