摘要
目的观察在七氟醚稳态吸入下,不同剂量舒芬太尼在无伤害性刺激时对脑电双频指数(BIS)、Narcotrend指数的影响。方法 48例全麻下行择期腹腔镜妇科手术患者,ASAⅠ或Ⅱ级,随机均分为四组。七氟醚吸入诱导,气管插管后调整七氟醚呼气末浓度为1.0MAC,维持15min后,A、B、C三组分别静注舒芬太尼0.25、0.5、1.0μg/kg,待BIS、Narcotrend值降低至最低点后,观察5min结束试验。D组给予生理盐水2ml。结果四组患者意识消失(LOC)、七氟醚达到稳态吸入(SS)时的BIS、Narcotrend值及舒芬太尼tmax比较差异均无统计学意义。与LOC时比较,SS时四组患者BIS、Narcotrend值均明显降低(P<0.01)。与给予舒芬太尼时(0min)比较,A、B、C三组BIS、Narcotrend值在给予舒芬太尼后均明显下降(P<0.05)。结论七氟醚麻醉下(1.0MAC),在无伤害性刺激时,舒芬太尼可降低BIS、Narcotrend值,且降低程度与剂量无关。
Objective To observe the effects of sulfentanil with various doses on the Bispectral index and Narcotrend index without nociceptive stimulus under the sevoflurane anesthesia.Methods Forty-eight ASA Ⅰ or Ⅱ patients undergoing gynecological operations were randomly divided into four groups（n=12）.All patients were induced with sevoflurane,the end-tidal concentrations of sevoflurane in all groups were adjusted to 1.0 MAC after tracheal intubation. Fifteen minutes later,sufentanil was injected in groups of B,C,D with the doses of 0.25,0.5,1.0 μg/kg respectively. The observations were finished when the values of Bispectral index and the Narcotrend index reached the minimum over 5 min. The values of Bispectral index and the Narcotrend index were recorded every minutes after the sufentanil injection. Results Among all groups,the BIS,Narcotrend values and tmax produced no statistical difference. Compared with the time when conscious lost,BIS and Narcotrend values were significantly lower when sevoflurane anesthesia reached steady state in all groups. The values of BIS and Narcotrend were significant lower after the injection of sufentanil in the groups of B,C and D（P0.05）. Conclusion Under the sevoflurane anesthesia with the steady end-tidal concentration of 1.0MAC,sufentanil could reduce the values of BIS and Narcotrend index without nociceptive stimulus without distinction among different doses.
出处
《临床麻醉学杂志》
CAS
CSCD
北大核心
2010年第12期1017-1019,共3页
Journal of Clinical Anesthesiology
关键词
七氟醚
舒芬太尼
麻醉深度
脑电双频指数
脑电描记术
Sevoflurane
Sufentanil
Depth of anesthesia
Bispectral index
Electroencephalography
