摘要
目的：探讨低分子肝素钙联合纳洛酮治疗急性脑梗死的疗效及安全性。方法：回顾性分析我院2004年4月~2009年2月收治入院的急性脑梗死患者110例临床资料,随机将110例患者分成两组。治疗组（55例）采用低分子肝素钙0.4 ml,脐周交替注射1次/12 h,共7 d;纳洛酮4 mg/d,分2次静脉滴注,共14 d。对照组（55例）采用低分子右旋糖酐（分子量为40 000）注射液,每日1次,每次500 ml,静脉滴注,2 h内滴完,连用7 d。分别观察两组治疗前后血液凝血酶原时间、纤维蛋白原、血小板恢复及临床神经功能评分和日常生活能力（ADC）评分。结果：治疗后,治疗组纤维蛋白原定量与治疗前比较差异有统计学意义（P〈0.05）,与对照组比较差异有高度统计学意义（P〈0.01）。治疗组神经功能缺损评分及总有效率明显高于对照组（P〈0.01）,均未发现出血性脑梗死或上消化道出血。结论：低分子肝素钙与纳洛酮联合应用治疗急性脑梗死安全,疗效确切,能减轻急性脑梗死患者神经功能缺损,提高患者独立生活能力,有明显的改善血液循环及脑保护作用。
Objective： To investigate the effect and safety of Low Molecular Weight Heparin combined with Naloxone in the treatment of acute cerebral infarction.Methods： Clinical data of 110 cases with acute cerebral infarction were analyzed retrospectively,who were admitted to hospital from April 2004 to February 2009,110 patients were randomly divided into two groups,55 patients treated with Low Molecular Weight Heparin 0.4 ml,paraumbilical alternation injection of 1/12 h,a total of 7 d;Naloxone 4 mg/d,intravenous infusion 2 times,a total of 14 d.Control group with Low Molecular Weight Dextran（molecular weight was 40,000） Injection,once a day,each 500 ml,intravenous infusion,2 h completed within the drops,a total of 7 d.Blood prothrombin time,fibrin the original,platelet recovery and clinical neurological function score and activities of daily living（ADC） score were observed respectively before and after treatment.Results： There was no statistical difference infibrinogen before treatment（P0.05）,treatment group was significantly improved after treatment（P0.01）,clinical neurological deficit scores and the total effective rate in treatment group were higher than the efficiency（P0.01）,and there was no hemorrhagic infarction or upper gastrointestinal bleeding.Conclusion： The Low Molecular Weight Heparin combined with Naloxone in the treatment of acute cerebral infarction is safe and effective.It can reduce neurological deficits in patients with acute cerebral infarction and improve the patients′ ability to live independently,significantly improve blood circulation and brain protection.
出处
《中国医药导报》
CAS
2011年第4期77-79,共3页
China Medical Herald
关键词
低分子肝素
脑梗死
药物治疗
Low Molecular Weight Heparin
Cerebral infarction
Drug therapy
