摘要
为探讨ｐ２１ｒａｓ和ｎｍ２３Ｈ１表达与胃癌淋巴结转移的关系，采用ＬＳＡＢ法观察了８０例胃癌患者的ｐ２１ｒａｓ和ｎｍ２３Ｈ１的表达，并分析其与淋巴结转移的关系。结果：有淋巴结转移（ＬＮＭ）组ｐ２１ｒａｓ表达阳性率（６２．５％）明显高于无ＬＮＭ组（４２．５％），但ｎｍ２３Ｈ１表达阳性率（２７．５％）则明显低于无ＬＮＭ组（４７．５％）；ＬＮＭ数为１～３枚的ｐ２１ｒａｓ表达阳性率（３３．３％）明显低于４～７枚和＞８枚的ＬＮＭ组（４５．８％和７１．４％）；Ｎ１组的表达阳性率（３６．４％）明显低于Ｎ２和Ｎ３组（５２．２％和８３．３％）。ＬＮＭ为１～３枚的ｎｍ２３Ｈ１表达阳性率（４４．４％）明显高于４～７枚和＞８枚的ＬＮＭ组（２５．０％和０％），ＬＮＭ为４～７枚组的ｎｍ２３Ｈ１表达阳性率明显高于＞８枚组；Ｎ１组ｎｍ２３Ｈ１表达阳性率（４５．５％）明显高于Ｎ２和Ｎ３组（２１．７％和０％）。上述结果提示，胃癌ｐ２１ｒａｓ和ｎｍ２３Ｈ１的表达与淋巴结转移密切相关，可作为胃癌患者预测转移和预后的指标。
To study correlation between expression of p21 ras and nm23H1 gene and status of
lymph node metastasis (LNM) in gastric cancer. The rate of positive expression of p21 ras and
nm23H1 were studied in 80 cases by LSAB immunohistochemical technique. Results: The
results showed that the positive expression of p21 ras in cases with LNM was 62.5%, higher
than that of cases without LNM (42.5%) (P<0.01); the positive rate of nm23H1 in cases with LNM
was 27.5%, lower than that of cases without LNM (47.5%) (P<0.01). The positive rate of p21 ras
in cases with 1-3 LNM was lower than that of cases with 4-7 or >8 LNM (P<0.01); the positive
rate of p21 ras in cases with N1 was lower than that of cases with N2 or N3 (P<0.01), there was
no positive expression of p21 ras in cases with N3 (7 cases). The positive rate of nm23H1 was
44.4% in cases with 1-3 LNM, higher than that of cases with 3-7 (25.0%) or >8 LNM (0%)
(P<0.01), the positive rate of nm23H1 in cases with N1 was markedly higher than that of cases
with N2 or N3, there was no positive expression of nm23H1 in cases with N3 (6 cases).
Conclusions: The results suggest that the expression of p21 ras and nm23H1 in gastric cancer
play an important role in the invasion growth and metastasis of tumor, and may serve as a
marker of predicting metastasis and prognosis of gastric cancer.
出处
《中国普外基础与临床杂志》
CAS
1999年第4期221-223,共3页
Chinese Journal of Bases and Clinics In General Surgery
