摘要
目的探讨肝硬化住院患者医院感染的临床特征。方法回顾性分析肝硬化发生医院感染患者的临床资料,观察医院感染部位、病原菌检查结果及其预后,比较80例医院感染患者与同期住院的无医院感染(非感染组)390例患者在年龄、性别、Child-Pugh分级、侵入性操作、并发症、抗菌药物应用、住院时间等的差异。结果感染部位以外源性感染46例:肺部感染24例、肠道感染16例、泌尿道感染6例;内源性感染34例:自发性腹膜炎24例、胆囊炎6例、胆管炎4例;送标本130份,104份检出病原菌:包括革兰阴性杆菌、革兰阳性菌、白色假丝酵母菌;两组比较感染组年龄大、Child-Pugh分级高、侵入性操作、并发症、预防应用抗菌药物、住院时间长等,差异有统计学意义(P<0.05);感染组中死亡率15.00%,高于非感染组的4.36%,差异有统计学意义(P<0.05)。结论肝硬化住院患者合并医院感染难以避免,对预后有不良影响,应该针对其临床特征实施相应措施。
OBJECTIVE To explore the clinical features of cirrhosis inpatients combined with nosocomial infection. METHODS A retrospective analysis of the clinical data of patients with liver cirrhosis was performed and the infected sites, the detection results of pathogens and the prognosis were observed, eighty cases of patients with nosocomial infection were compared with no nosocomial infection 390 patients in the age, sex, money-Pugh classification, invasive operation, coexist, antibiotics and hospitalization time. RESULTS There were 46 cases of infected sites exogenous infections , including 24 patients with pulmonary infection, intestinal infection in 16 cases and urinary tract infection in 6 cases. Endogenous infection were 34 cases, including 24 cases of spontaneous peritonitis, 6 cases of cholecystitis and 4 cases cholangitis. 104 cases of pathogens were detected from 130 cases of submitted specimens, including G- bacili, G＋ bacteria and Candida albicans. The older aged, higher Child-Pugh grading, invasive operation, complications, preventive application of antibiotics and longer hospitalization were in the infection group （P〈0.05）. The mortality in infection group （15.00%） than that of the non-infection group （4. 36%）, the difference was statistically significant （P〈0. 05）. CONCLUSION Cirrhosis inpatients combined with nosocomial infection are difficult to avoid and have bad prognosis. The corresponding measures should be implemented in accordance with clinical features.
出处
《中华医院感染学杂志》
CAS
CSCD
北大核心
2011年第4期685-686,共2页
Chinese Journal of Nosocomiology
关键词
肝硬化
医院感染
临床特征
Cirrhosis
Nosocomial infection
Clinical features
