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依达拉奉对脑出血大鼠急性期脑水肿与神经行为学的影响 被引量：3

Effects of edaravone on brain edema and neurological behavior in rats of acute intracerebral hemorrhage
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摘要 目的评价自由基清除剂依达拉奉对脑出血大鼠急性期脑水肿与神经行为学的影响。方法将大鼠分为假手术组、实验对照组与依达拉奉干预组,采用戊巴比妥钠麻醉大鼠,应用立体定向技术制备SD大鼠脑出血模型,根据实验需要,分别给予各组不同的处理方式,观察大鼠神经行为学改变,24 h后处死大鼠,检测大鼠脑组织含水量。结果与假手术组相比,实验对照组大鼠脑组织含水量升高,而神经缺损评分增加;与实验对照组相比,依达拉奉干预组大鼠脑组织含水量减少,神经功能缺损评分降低。结论依达拉奉能够减轻脑出血急性期的脑水肿与神经功能缺损。
作者 杨秀丽 师冉 郭联
机构地区 青岛市海慈医疗集团神经内科 山东中医药大学附属医院神经内科
出处 《中华疾病控制杂志》 CAS 2011年第2期175-177,共3页 Chinese Journal of Disease Control & Prevention
关键词 脑出血 依达拉奉 脑水肿 行为
分类号 R743.34 [医药卫生—神经病学与精神病学]
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参考文献11

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二级参考文献30

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共引文献123

同被引文献23

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引证文献3

二级引证文献15

中华疾病控制杂志
2011年 第2期

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