摘要
目的:研究柴胡与葛根配伍在解热、抗炎等方面的作用。方法:56只雄性SD大鼠,随机分为空白组、模型组、阿司匹林组、柴胡组、葛根组、柴胡葛根3∶2组、柴胡葛根4∶5组共7组,每组8只,除空白组外,其余大鼠采用20%的干酵母悬液10 mL.kg-1大鼠背部皮下注射,建立发热模型。观察柴胡、葛根及其不同配伍比例的各组中药煎剂10 g.kg-1对发热大鼠的体温以及血清中炎性介质白介素-1β(IL-1β)含量、髓过氧化物酶(MPO)活性的影响。结果:柴胡、葛根及其不同配伍比例均具有降低发热大鼠体温和血清中IL-1β,MPO的作用,与模型组比(P<0.05或P<0.01)但配伍应用后作用明显优于单味柴胡或葛根。结论:柴胡与葛根配伍在解热、抗炎等方面具有显著的协同增效作用,发挥解热、抗炎的最佳配伍比例为柴胡葛根4∶5。
Objective：To study the effect of Chinese thorowax root（CTR）and lobed kudzuvine root（LKR） compatible application on relieving fever rats and anti-inflammation.Method：the fever rat models are induced with back hypodermic injection of 20% dry yeast suspensions,observing the influence of CTR,LKR and their different com-patible proportions of decoction 10 g.kg-1 on body temperature of fever rats and the serum content of Interleukin-1β（IL-1β）and activity of myeloperoxidase（MPO）.Result：The different compatible proportions of CTR and LKR,CTR,and LKR can relieve fever,anti-inflammation compared to model group（P 〈 0.05 or P 〈 0.01）,but the effect of that compatible application obviously outstripped CTR or LKR only.Conclusion：The effect of CTR and LKR has signifi-cant synergistic effect on the aspects of relieving fever,anti-inflammation and so forth.The best compatible proportion of CTR and LKR on relieving fever,anti-inflammation is 4：5
出处
《中国实验方剂学杂志》
CAS
北大核心
2011年第5期207-209,共3页
Chinese Journal of Experimental Traditional Medical Formulae
关键词
柴胡
葛根
配伍
发热大鼠
Chinese thorowax root
lobed kndzuvine root
compatibility
fever rats
