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高迁移率族蛋白1mRNA表达与子宫内膜癌临床病理特征的关系 被引量：6

Correlation with expression of HMGB1 mRNA and clinicopathological features of endometrial carcinoma
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摘要 目的通过检测高迁移率族蛋白1（High mobility group protein1，HMGB1）mRNA在子宫内膜癌中的表达，探讨HMGBI基因与子宫内膜癌临床病理特征的关系。方法应用半定量RT—PCR技术检测56例子宫内膜癌和20例正常子宫内膜中HMGB1 mRNA的表达情况。结果子宫内膜癌组织和正常子宫内膜组织HMGB1 mRNA的表达水平分别为0．3512±0．0985和0．2208±0．0170，内膜癌组高于正常内膜组，差异有统计学意义（P〈0．05）；子宫内膜癌按不同的临床病理特征分组，HMGB1 mRNA表达的相对含量随手术病理分期的增加、淋巴结的转移和肌层浸润的加深出现上调的趋势，差异均有统计学意义（P〈0.05）。结论HMGB1 mRNA的表达与子宫内膜癌的临床病理特征有关，HMGB1可能参与子宫内膜癌的发生、发展、浸润和转移过程。 Objective To investigate the expression of HMGB1 mRNA .in endometrial carcinoma and its correlation with clinicopathological features of endometrial carcinoma. Methods Semi-quantitative RT-PCR method was used to detect the expression level of HMGB1 gene in 56 cases of endometrial carcinoma and 20 cases of normal endometrium. Results The expression of HMGB1 mRNA in endometrial carcinoma （0. 3512 ±0. 0985） was significantly higher than that in normal endometrium （0. 2208 ±0. 0170）. There was a significant difference in the two groups（ P 〈 0. 05 ）. Grouping by clinicopathological features, the expression of HMGB 1 mRNA in endometrial carcinoma had a correlation with clinical-surgical stage （ P 〈 0. 05）, metastasis of lymph nodes （ P 〈 0. 05 ）, and depth of myometrial invasion （ P 〈 0. 05 ）. Conclusion The high level of HMGB1 mRNA indicated that HMGBI might play an essential role in the genesis, growth, invasion and metastasis of endometrial carcinoma.
作者 谢日学 吴佳捷 谢颖 萧梅芳 周翠香
机构地区 中南大学湘雅医院妇产科
出处 《中国医师杂志》 CAS 2011年第1期41-43,48,共4页 Journal of Chinese Physician
关键词 高迁移率族蛋白质类/代谢 子宫内膜肿瘤/代谢/病理学 High mobility group proteins/ME Endometrial neoplasms/ME/PA
分类号 R737.33 [医药卫生—肿瘤]
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参考文献8

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二级参考文献29

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共引文献11

同被引文献53

  • 1冯力元,吴佳捷.小干扰RNA抑制HMGB1表达对子宫内膜癌细胞侵袭与迁移的影响[J].中南大学学报（医学版）,2014,39(1):36-42. 被引量：14
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中国医师杂志
2011年 第1期

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