摘要
目的：观察肺炎支原体（MP）肺炎患儿血清白胞介素8（IL-8）和白细胞介素10（IL-10）的变化及阿奇霉素治疗对其的影响。方法：以2007年1月2010年5月连续收治的MP肺炎患儿56例为研究对象（MP组）,给予阿奇霉素治疗,疗程7天;同时选择同期的健康儿童50例为正常对照组。用ELISA法检测两组治疗前后血清IL-8和IL-10水平的变化,观察阿奇霉素治疗MP肺炎的临床疗效。结果：阿奇霉素治疗MP肺炎总有效率为96.4%。与正常对照组比较,MP组治疗前血清IL-8水平显著升高,IL-10水平明显下降（均P〈0.05）;阿奇霉素治疗后,MP组患儿血清IL-8水平下降,IL-10水平升高,接近正常对照组（均P〈0.05）。结论：阿奇霉素可降低肺炎支原体肺炎患儿血清IL-8水平。
Objective：To observe the changes of serum interleulkin-8（IL-8） and interleulkin-10（IL-10） in children with mycoplasma pneumoniae and the effect of azithromycin.Methods：56 children with mycoplasma pneumoniae from January 2007 to May 2010 were selected as study objects（mycoplasma pneumoniae group）,then they were treated with azithromycin for 7 days,50 healthy children at the same period were selected as normal control group;ELISA was used to detect the changes of serum levels of IL-8 and IL-10 before and after treatment in the two groups,the clinical efficacy of azithromycin in treatment of mycoplasma pneumoniae was observed.Results：The total effective rate of azithromycin was 96.4%.Compared with control group,the serum level of IL-8 increased significantly,and the serum level of IL-10 decreased significantly in mycoplasma pneumoniae group before treatment（all P〈0.05）.After treatment with Azithromycin,the serum level of IL-8 decreased,and the serum level of IL-10 increased in mycoplasma pneumoniae group（all P〈0.05）.Conclusion：Azithromycin can reduce the serum level of IL-8 and increase the level of IL-10 in children with mycoplasma pneumoni
出处
《中国妇幼保健》
CAS
北大核心
2011年第6期922-923,共2页
Maternal and Child Health Care of China
