摘要
目的：探讨绝经前、后妇女血清性激素变化与脂质代谢以及与心血管疾病的关系。方法：100例45岁~55岁绝经前、后妇女分成两组：绝经前组50例与绝经组50例,分别测定血清性激素变化和血脂水平,并进行相关性分析。同时观察两组心血管疾病的发病情况。结果：绝经组血清雌二醇（E2）、高密度脂蛋白胆固醇（HDL-C）水平明显低于绝经前组（P〈0.01或P〈0.05）;促卵泡激素（FSH）、黄体生成素（LH）、总胆固醇（TC）、甘油三酯（TG）、低密度脂蛋白胆固醇（LDL-C）、TG/HDL-C、LDL-C/HDL-C水平均明显高于绝经前组（P〈0.05或P〈0.01）;绝经后组与绝经前组相比,妇女E2与TC、TG、LDL-C水平呈负相关;绝经组冠心病（CHD）患病率明显高于绝经前组（P〈0.05）。结论：绝经后妇女E2、HDL-C水平明显下降,FSH、LH、TC、TG、LDL-C、TG/HDL-C、LDL-C/HDL-C水平均明显升高,CHD发病增加,表明绝经后妇女性激素变化、血脂异常且与心血管病的发生有关。
Objective：To investigate the correlations between the serum sex hormones and lipid metabolism or cardiovascular disease in menopausal women.Methods： 100 cases of premenopausal and postmenopausal women aged 45~55 were divided into two groups： one group was 50 cases of premenopausal women;the other group was 50 cases of postmenopausal women.The sex hormones and lipid levels in serum were measured.And the correlations were statistically analyzed.The incidences of cardiovascular diseases of the two groups were observed.Results： The levels of estradiol（E2） and high-density lipoprotein cholesterol（HDL-C） in serum of postmenopausal women were lower than that of premenopausal women.The difference was statistically significant（P0.01 or P 0.05）.However,the follicle-stimulating hormone（FSH）,corpus luteum（LH）,total cholesterol（TC）,triglyceride（TG）,low density lipoprotein cholesterol（LDL-C） and TG/HDL-C,LDL-C/HDL-C in serum of postmenopausal women were higher than that of premenopausal women.The difference was statistically significant（P0.01 or P0.05）.The correlations between the levels E2 and TC,TG or LDL-C in postmenopausal women were negative,compared with premenopausal women.The incidence of coronary heart disease（CHD） in the postmenopausal group was obviously higher than that in the premenopausal group.The difference was statistically significant（P0.05）.Conclusion： E2 and HDL-C in postmenopausal women drop,while FSH,LH,TC,TG,LDL-C,TG/HDL-C and LDL-C/HDL-C in postmenopausal women are elevated;the incidence of CHD increase.The results suggest there are the correlations between the serum sex hormones in postmenopausal women and lipid metabolism or cardiovascular disease.
出处
《中国卫生检验杂志》
CAS
2011年第2期369-370,共2页
Chinese Journal of Health Laboratory Technology
关键词
绝经前后妇女
性激素
脂质代谢
心血管疾病
Menopausal women
Hormones
Lipid metabolism
Cardiovascular disease
