摘要
目的对抗氧化剂治疗重症急性胰腺炎的有效性分析。方法一个随机、安慰剂对照实验,将2002年4月—2006年10月44例患者分成两组,每组22例,抗氧化剂组使用N-乙酰半胱氨酸、硒剂、维生素C静脉滴注,安慰剂组使用安慰剂,治疗7d,在6个观察时间点记录患者的APACHE-Ⅱ评分,Marshall器官功能障碍评分,LODS器官功能障碍评分和血清抗氧化剂水平。结果抗氧化剂组在治疗后3~7d,APACHE-Ⅱ评分明显低于安慰剂组,差异有统计学差异（P〈0.05）,多器官功能障碍发生人数也低于安慰剂组,差异有统计学差异（P〈0.05）,抗氧化剂组病死率为4.5%,安慰剂组病死率高达18%,重症监护时间及住院时间均明显缩短。结论抗氧化剂在治疗重症急性胰腺炎时,能有效减少重症急性胰腺炎及其并发症的发生率和病死率,减轻细胞损害。
Objective To observe the effect of intravenous antioxidant therapy to be used for the treatment of severe acute pancreatitis.Methods A randomised,placebo controlled trial of intravenous antioxidant（n-acetylcysteine,selenium,vitamin C） therapy in patients with predicted severe acute pancreatitis was been conducted.44 patients were enrolled and distribute into two groups（22 cases per group,one treated by antioxidant,another by placebo） over the period April 2002 to November 2006.APACHE-Ⅱ score,Marshall organ dysfunction score,logistic organ dysfunction score and measurement of antioxidant levels were recorded at six time points.Results During 3 to 7 days,there was statistically significant difference on the APACHE-Ⅱ score（P0.05）,the incidence rate of MODS and death rate of intervention group were lower than placebo group.Days in admission and ICU of intervention group also fewer than placebo.Conclusion This study provides evidence to justify antioxidant therapy was effective in severe acute pancreatitis,which can reduce the incidence rate of MODS and death rate and cut down the Length of stay.
出处
《实用心脑肺血管病杂志》
2011年第2期217-219,共3页
Practical Journal of Cardiac Cerebral Pneumal and Vascular Disease
关键词
抗氧化剂
重症急性胰腺炎
研究
Antioxidant
Severe acute pancreatitis
Research
