摘要
以玉米蛋白为壁材,白藜芦醇为模型药物,采用超临界CO2抗溶剂法制备负载白藜芦醇的玉米蛋白纳米粒,考察了过程参数压力、温度以及芯材质量比对白藜芦醇在纳米粒中负载量的影响。用紫外光谱分析、扫描电镜、X射线衍射分析等方法对样品进行了表征,并且对释放度进行研究。结果表明,随着超临界CO2压力的增加,白藜芦醇的负载量降低;随着温度和芯材质量比的增加,白藜芦醇的负载量升高。玉米蛋白和白藜芦醇形成Matrix结构,纳米粒为均匀球形颗粒。释放度实验显示,纳米粒中白藜芦醇的释放速度比原料的释放速度慢,有缓释作用。
Supercritical CO2 anti-solvent technology was tested in preparing zein nanoparticles loaded with resveratrol.The effects of different operating parameters,such as pressure,temperature,and ratio,on the loading weight of resveratrol were investigated.UV,SEM,XRD were used to characterize the products.The release behavior of resveratrol from the prepared nanoparticles was also studied.Results show that the yield of resveratrol is lower when CO2 pressure increases,while the loading yield is higher with an increase of temperature and ratio.The structure of resveratrol-loaded zein nanoparticle is a Matrix with a well-distributed sphere shape.Furthermore,vitro drug release studies show that the products exhibit a slower release than the single resveratrol.
出处
《精细化工》
EI
CAS
CSCD
北大核心
2011年第3期270-274,共5页
Fine Chemicals
基金
国家高技术研究发展计划(863)项目(2007AA10Z350)
国家自然科学基金项目(20976103)~~
