摘要
目的探讨SIMCA(soft independent modeling of class analogy)法对肝炎后肝硬化中医证候判识的可行性。方法在对变量进行归一化处理的基础上,用SIMCA法对268例肝炎后肝硬化患者临床症状、体征和生物学指标进行分析,获得相应SIMCA距离并以之对肝硬化证候进行识别,再运用秩和检验分析误判原因。结果 5种中医证候(肝郁脾虚证、肝肾阴虚证、脾肾阳虚证、湿热内蕴证及瘀热蕴结证)的识别率在最近类中为72.39%,在次近类中为17.91%,总识别率为90.30%。其中,对肝肾阴虚证的识别率最高,总识别率为95.24%。秩和检验分析结果表明,在最近类中,未得到识别者与得到识别者比较,在某些对证候判识起关键作用的症状变量得分方面差异有统计学意义(P<0.05)。结论采用SIMCA法对肝炎后肝硬化中医证候进行判识,与临床实际证候拟合度较高。依据SIMCA法建立证候辨识系统可为中医证候判别提供参考。
Objective To explore the feasibility of Chinese medical syndrome identification in patients with post-hepatitis cirrhosis （PHC） by soft independent modeling of class analogy （SIMCA）. Methods After variants were normalized,SIMCA was used to analyze clinical symptoms,physical signs,and biological parameters in 268 PHC patients,and the obtained distance of SIMCA was used to identify the syndromes of PHC. Some incorrect reasons were then tested by Mann-Whitney test. Results The recognition rates of 5 Chinese medical syndromes （Gan depression and Pi deficiency syndrome,Gan-Shen yin-deficiency syndrome,Pi-Shen yang-deficiency syndrome,inner accumulation of dampness-heat syndrome,and stasis-heat accumulation syndrome） were 72.39% in the nearest class,and 17.91% in the sub-near class,as well as the total recognition rate was 90.3%. The highest recognition rate （95.24%） presented in the recognition on Gan-Shen yin-deficiency syndrome. Among some vital symptom variants of nearest class,significant difference could be found between identified and un-identified syndromes （P0.05）. Conclusion Identification of Chinese medical syndromes by SIMCA has rather higher goodness-of-fit with clinical practice,to set up a SIMCA depended syndrome identifying system could offer a useful reference for Chinese medical syndrome identification.
出处
《中国中西医结合杂志》
CAS
CSCD
北大核心
2011年第2期177-181,共5页
Chinese Journal of Integrated Traditional and Western Medicine
基金
中国博士后基金资助项目(No.20070420106)
国家重点基础研究发展计划(973计划)资助项目(No.2006CB504801)
上海市重点学科建设项目资助(No.Y0302)
上海市教育委员会E-研究院建设计划资助项目(No.E03008)
上海市教育委员会高校高水平特色发展项目--中医复杂系统研究(上海市教委财2005-81)
关键词
SIMCA法
肝炎后肝硬化
证候
症状
生物学指标
soft independent modeling of class analogy
post-hepatitis cirrhosis
Chinese medical syndrome
symptom
biological parameters
