摘要
目的探讨槲皮素对力竭运动疲劳大鼠血清自由基代谢和运动能力的影响,为抗疲劳功能食品的研制提供科学依据。方法雄性SD大鼠随机分为正常安静对照组(对照组)、力竭游泳疲劳组(疲劳组)和力竭游泳疲劳+槲皮素50 mg/kg组(槲皮素组),每组10只。采用一次性力竭游泳运动建立力竭疲劳模型,记录各组大鼠力竭游泳活存时间,测定血清MDA含量、SOD和GSH-Px活力。结果槲皮素组大鼠力竭游泳活存时间为(348.5±52.4)min,明显长于疲劳组〔(171.7±37.1)min,P<0.01〕;血清MDA含量为(4.4±1.0)nmol/ml,明显低于疲劳组〔(6.2±1.9)nmol/ml,P<0.01〕;SOD和GSH-Px活力分别为(105.0±3.4)和(873.6±72.3)U/ml,均明显高于疲劳组〔分别为(80.5±4.2)和(538.6±63.6)U/ml,P<0.01〕。结论槲皮素可以提高力竭运动疲劳大鼠血清抗氧化酶活力,减轻脂质过氧化反应,提高大鼠运动能力。
Objective To investigate the effects of Quercetin（QC） on oxidative stress induced by exhausted swimming in rats,so as to provide scientific basis for developing anti-fatigue food.Methods Male SD rats were randomly divided into resting control group,exhausted swimming group,and exhausted swimming with administration of Quercetin group.The content of malondialdehyde（MDA）,the activity of superoxide dismutase（SOD）and glutathione peroxidase（GSH-Px） in blood serum were measured.At the same time the survival time after exhausted swimming was determined.Results The survival time in exhausted swimming＋Quercetin group was longer than exhausted swimming group（（348.5±52.4）min vs（171.7±37.1）min,P0.01）.The content of MDA in exhausted swimming＋QC group was lower（（4.4±1.0） nmol/ml vs（6.2±1.9） nmol/ml,P0.01）,whereas the activity of SOD,and GSH-Px was higher（（105.0±3.4）U/ml vs（80.5±4.2）U/ml,（873.6±72.3）U/ml vs（538.6±63.6）U/ml respectively,P0.01）than in exhausted swimming group.Conclusion Quercetin could increase the antioxidative enzyme activity,decrease the lipid peroxidation,thus enhance the ability of exercise in exhausted fatigue rats.
出处
《解放军预防医学杂志》
CAS
2011年第1期19-21,共3页
Journal of Preventive Medicine of Chinese People's Liberation Army
基金
浙江省教育厅科研基金项目(No.20070912)
关键词
疲劳
力竭运动
槲皮素
自由基
fatigue
exhausted exercise
Quercetin
free radicals
