摘要
目的观察卵巢上皮性癌(卵巢癌)组织中表皮生长因子受体(EGFR)与信号转导和转录激活因子3(STAT3)mRNA的表达,并探讨其意义。方法用RT-PCR技术检测13例正常卵巢、11例卵巢良性肿瘤及43例卵巢癌组织中的EGFR mRNA和STAT3 mRNA。结果卵巢上皮性癌组织中EGFR、STAT3 mRNA阳性表达率显著高于正常卵巢及卵巢良性肿瘤组织(P均<0.05)。卵巢上皮性癌组织中EGFR、STAT3 mRNA表达均与卵巢癌病理分期有关,与患者年龄、肿瘤分化程度、组织学类型及有无淋巴结转移等临床病理参数无关(P均>0.05);卵巢癌组织中EGFR和STAT3 mRNA表达有显著相关性(r=0.42,P<0.01)。结论卵巢癌组织中EGFR、STAT3表达上调。二者在卵巢癌的发生发展中起重要作用。
Objective To study the expression and significance of epidermal growth factor receptor（EGFR） and signal transducer and activator of transcription 3（STAT3） mRNA in ovarian cancer.Method Reverse transcription polymerase chain reaction（RT-PCR） was performed to detect the expression of EGFR and STAT3 mRNA in 13 cases of normal ovaries,11 cases of benign ovarian tumors and 43 cases of ovarian epithelial cancers,and then the correlation between them was analyzed.Results EGFR and STAT3 mRNA expression in ovarian epithelial cancers was significantly higher than in normal ovarian tissue and benign ovarian tumors（P0.05）.Also the expression of EGFR and STAT3 mRNA was correlated with surgical stage of ovarian epithelial cancer,their expression inⅢ and Ⅳ stage was higher than in I and Ⅱstage（P0.05）,but their expression has no correlation with patient ages,tumour differentiation degree,histological type and lymph node metastasis（P0.05）.There is a positive correlation between EGFR and STAT3（r=0.42,P0.01）.Conclusions EGFR and STAT3 play an important role in the occurence and development of ovarian cancer,the detection of EGFR,STAT3 and EGFR-STAT3 signaling pathway are expected to be an indicator in early diagnosis of ovarian cancer,and may become a new therapeutic target.
出处
《山东医药》
CAS
北大核心
2011年第6期12-14,共3页
Shandong Medical Journal
关键词
卵巢肿瘤
卵巢上皮性癌
表皮生长因子受体
信号转导和转录激活因子3
ovarian neoplasm
epithelial ovarian cancer
epidermal growth factor receptor
signal transducer and activator of transcription
