摘要
目的探讨不同治疗策略及治疗反应对小细胞肺癌（SCLC）预后的影响。方法收集2002年1月~2010年1月住院化疗的小细胞肺癌患者,回顾分析其治疗过程,并对其随访。对可能的危险因素进行单因素分析,P〈0.1的因素进入Cox风险比例回归模型。结果住院接受化疗的小细胞肺癌患者共76例,局限期43例,1、2和5年生存率分别为81%、56%和21%;广泛期33例,1和2年生存率分别为59%和24%。单因素分析放化疗联合治疗、一线化疗最佳疗效为有效（CR＋PR）为生存相关因素;接受手术治疗为局限期患者生存相关因素。Cox风险比例回归模型多因素分析,上述因素均为独立相关因素。结论放化疗联合治疗、提高一线方案疗效、局限期早期患者接受手术治疗可能会提高患者生存。
Objective To explore the outcomes of different treatment and different responses on the prognosis of small cell lung cancer.Methods Collect patients diagnosed as small cell lung cancer and admitted to our department for chemotherapy from Jan 2002 to Jan 2010 to review records.Analyze the potential variables and only factors associated with survival with a P value less than 0.1 in univariate analysis were introduced into the Cox regression model.Results Seventy-six cases were enrolled in this study.For local stage,1-year,2-year and 5-year survival rate are 81%,56%,21%,respectively.For extend stage,1-year and 2-year survival rate are 59% and 24%.Chemotherapy combined with radiotherapy,CR＋PR obtained in first-line chemotherapy are associated with survival.For local stage,complete resection is associate with survival.In Cox regression,the variables above are all independent factors of survival.Conclusion Chemotherapy combined with radiotherapy increases the effectiveness of first-line regimen,and complete resection for selected local stage patient may be a potential approache to improve survival of small cell lung cancer patients.
出处
《基础医学与临床》
CSCD
北大核心
2011年第3期312-315,共4页
Basic and Clinical Medicine
关键词
小细胞肺癌
治疗
预后
多因素分析
small cell lung cancer
treatment
prognosis
multivariate analysis
