摘要
目的:探索血清脂联素在胃癌患者的表达水平及在胃癌不同临床病理因素之间的差异。方法:收集95例胃癌患者血清样本。同时选择30例正常人血清作为对照。检测并比较不同分组患者的血清脂联素、血清总胆固醇(TC),甘油三酯(TG),高密度脂蛋白胆固醇(HDL-C)和低密度脂蛋白胆固醇(LDL-C)水平。结果:与正常人群相比,胃癌患者具有较低的血清脂联素和较高的血脂水平。而早期转移的胃癌患者血清脂联素水平进一步降低,血脂水平更高。胃癌患者血清脂联素和TC、LDL-C、HDL-C均存在负相关,并且有显著性(P<0.05)。结论:低血清脂联素与胃癌患者的淋巴结转移相关,可能成为反应胃癌患者疾病进展的一个血清指标。
Objective To explore the expression level of serum adiponectin in patients with gastric cancer and analyze its relationships with tumor progression. Methods 95 gastric cancer patients and 30 healthy control were enrolled in this study. Serum adiponectin, total cholesterol （TC）, triglycerides （TG）, high-density lipoprotein cholesterol （HDL-C） and low density lipoprotein cholesterol （LDL-C） were detected and compared among different groups. Results As compared with the healthy controls, the patients had lower adiponectin levels and elevated lipid levels. Patients with early metastasis had lower adiponectin levels and higher lipid levels than those without metastasis. Serum adiponectin was negatively related with TC, LDL-C, and HDL-C in the patients （P 〈 0.05）. Conclusions Serum adiponeetin level is associated with gastric cancer with lymph node metastasis, which may be used as a serum marker to evaJuate the progression of gastric patients.
出处
《实用医学杂志》
CAS
北大核心
2011年第6期976-978,共3页
The Journal of Practical Medicine
关键词
胃肿瘤
脂联素
高脂血症
Stomach neoplasms
Adiponectin
Hyperlipidemia
