摘要
目的评价超声引导下经皮穿刺(UGP)瘤体内注射平阳霉素治疗大块型及巨块型肝血管瘤的临床疗效。方法 219例肝血管瘤患者,包括大块型肝血管瘤(瘤体直径7～10cm)147例和巨块型肝血管瘤(瘤体直径≥10cm)72例。采用平阳霉素在超声引导下经皮多点、多面、多次性穿刺注射肝血管瘤体内,每5～7d注射1次,注射6～8次为1个疗程。平阳霉素总量不超过112mg。治疗后3个月开始应用二维超声评价治疗效果,评估终点为治疗后2年。结果本组肝血管瘤瘤体在治疗期间不能完全消失,治疗后时间越长,瘤体缩小越明显。1个疗程治疗后瘤体消失完全或仅残余0.5～1.0cm小结节者176例(80.37%),瘤体缩小在75%以上者43例(19.63%),总有效率100%。全组无肝肾功能损害等严重并发症,无死亡病例。并发腹腔内出血3例。结论超声引导下经皮穿刺瘤体内注入平阳霉素治疗巨大肝血管瘤的方法,具有安全、创伤小、疗效确切并容易为患者所接受等优点。
Objective To evaluate the efficacy of Pingyangmycin injection with puncture for large and massive hepatic hemangioma guided by ultrasound.Methods A total of 219 patients suffered from large and massive hepatic hemangioma were diagnosed including a large group of 147 cases（diameter 7-10 cm） and a massive group of 72 cases（diameter ≥10 cm）.Pingyangmycin was injected into the hemangioma from different spots and directions at different times under the guidance of ultrasound.The injection was performed once within a 5-7 days for interval and 6-8 times for a course of treatment.The total amount of Pingyangmycin was not beyond 112 mg.The effectiveness was evaluated after 3 months of injection by ultrasound and the terminal point of evaluation was 2 years after treatment.Results The tumor could not vanish during the treatment.The length of time after treatment is related to the decrease of tumors.After treatment,176（80.37%） cases of tumors vanished or a small nodule with 0.5-1.0 cm was found.Forty-three（19.63%） cases of tumors decreased by 75% with an efficacy rate of 100%.No severe complications of hepatic,renal functional impair and death were reported.There were 3 cases complicated with intraperitoneal hemorrhage.Conclusion The method of puncture with pingyangmycin injection guided by ultrasound for huge hepatic hemangioma are effective and acceptable by patients with less injury.
出处
《中华医学超声杂志（电子版）》
2010年第11期64-67,共4页
Chinese Journal of Medical Ultrasound(Electronic Edition)
关键词
超声检查
肝血管瘤
平阳霉素
Ultrasonography
Hepatic hemangioma
Pingyangmycin
