摘要
目的:通过对反复自然流产夫妇的染色体核型进行分析,探讨反复自然流产与染色体核型异常的关系。方法:对1018对诊断为反复自然流产的夫妇,采集肘静脉血液,常规外周血细胞培养和染色体标本制备,行染色体核型分析。结果:1018对反复自然流产患者中,染色体异常者129例,占受检夫妇的12.67%。其中,平衡易位24例;罗伯逊易位12例;染色体多态80例;倒位11例;重复2例。结论:染色体核型异常是造成流产、死胎的重要因素之一,对反复自然流产患者进行细胞遗传学检查具有重要意义。
Objective： To analyze the incidence of abnormal karyotypes and clinical value of chromosome analysis in spontaneous abortion.Methods： Chromosome analysis was performed on 1018 couples who were diagnosed spontaneous abortion in January 1996 ～ June 2010.Results： 129 abnormal karotypes were detected in 1018 cases（12.67%）,including 24 cases of balanced reciprocal translocation and 12 cases of Robertsonian translocations;80 cases of chromosome polymorphism;11 cases of inversions and 2 cases of duplication.Conclusion： Chromosome abnormality is one of the important factors of miscarriage and stillbirth.It is significant to analyze chromosomal in patients with early recurrent spontaneous abortion.
出处
《现代生物医学进展》
CAS
2010年第24期4707-4709,共3页
Progress in Modern Biomedicine
关键词
自然流产
染色体
核型
Spontaneous abortion
Chromosome
Karyotype analysis
