摘要
目的观察益气化痰祛瘀方对冠心病大鼠血清一氧化氮(NO)和血浆内皮素(ET)的影响并探讨其机制。方法采用喂饲高脂饲料和腹腔注射脑垂体后叶素的方法复制冠心病大鼠模型,实验分组为正常组、模型组、复方丹参滴丸对照组、益气化痰祛瘀方高、低剂量组,施加相应药物干预后,测定各组大鼠血清NO和血浆ET含量。结果模型组大鼠NO含量较正常组明显降低(P<0.01),ET含量较正常组明显升高(P<0.01);与模型组比较,各用药组大鼠NO含量明显升高(P<0.05或P<0.01),ET含量明显降低(P<0.05或P<0.01);高、低剂量组在升高NO和降低ET方面均优于对照组(P<0.05)。结论益气化痰祛瘀方可能通过升高NO含量、降低ET含量,保护血管内皮功能,治疗冠心病。
Objective To observe the effects of prescription Yiqi Huatan Quyu on the NO content in the serum and ET content in the plasma of the coronary heart disease（CHD） rats and explore possible mechanism.Methods The model of CHD rats was established by feeding high fat forage and injecting pituitrin in the abdominal cavity.Then these rats were divided into normal,model,compound danshen drop pill control,high dose,low dose groups.Then NO content in the serum and ET content in the plasma were measured in all groups.Results NO content of model group was significantly reduced in comparison with that of normal group（P0.01）.ET content of model group was significantly increased in comparison with that of normal group（P0.01）.NO content increased remarkably（P0.05,P0.01） and ET content was much lower（P0.05,P0.01） of each treatment group in comparison with that of model group.The effect of increasing NO content and reducing ET content of high and low dose groups were much better than those of control group（P0.05）.Conclusions Prescription Yiqi Huatan Quyu has the effect of increasing NO contents and reducing ET contents significantly.It could treat CHD by protecting vascular endothelial function.
出处
《中国老年学杂志》
CAS
CSCD
北大核心
2011年第5期814-815,共2页
Chinese Journal of Gerontology
基金
河北省科技厅支撑计划课题(08276101D-37)
