摘要
目的:探讨CD44s、CD44v6、CD44v3的表达水平与大肠癌生物学特性之间的关系及临床意义。方法:应用Envision TM免疫组化法,检测57例大肠癌组织标本和20例癌旁正常组织中CD44s、CD44v6、CD44v3的表达水平。结果:57例结直肠癌的组织标本中CD44s、CD44v6、CD44v3的阳性表达率为分别66.67%、63.16%、70.18%,而在20例正常组织中基本不表达,二者间具有统计学差异(P<0.01)。CD44s、CD44v6、CD44v3阳性表达与临床分期、肿瘤细胞分化程度显著性相关(P<0.05)。CD44v6、CD44v3阳性表达还与淋巴结转移显著相关。大肠癌组织中CD44s、CD44v6、CD44v3阳性,阴性表达的患者5年生存率分别为55.26%,78.95%;52.79%,80.95%;52.50%,88.24%,CD44s二者间差异无统计学意义(P>0.05);CD44v6、CD44v3二者间差异具有统计学意义(P<0.01)。生存率分析显示CD44s、CD44v6、CD44v3均是对生存有影响的因子。结论:黏附分子CD44s、CD44v6、CD44v3可能参与了大肠癌的发生与转移,检测其表达水平有助于预后判断。
Objective：To explore the expression of CD44 protein in human colorectal carcinoma and its clinical significance.Methods：In 57 cases of colorectal carcinoma tissues and 20 cases of normal tissues near colorectal carcinoma tissues,expression of CD44s,CD44v3 and CD44v6 detected by immunohistochemically.Results：In 57 tumor tissues,the positive rates of CD44s,CD44v6,CD44v3 protein were 66.67%,63.16%,70.18%,respectively.In 20 cases of the normal tissues near colorectal carcinoma tissues,the expression rates of CD44s,CD44v6,CD44v3 protein were negative.There was significant correlation between CD44s,CD44v6,CD44v3 expression and the clinical stage,differentiation of tumor（P0.05）.There was also significant correlation between CD44v6,CD44v3 expression and lymph node metastasis（P0.05）.5-year survival rates were 88.24%,52.50%;80.95%,52.78% in negative cases and positive cases of CD44v3,CD44v6 respectively.The differences between the two groups were significant（P 0.01）.For CD44s,5-year survival rates were 78.95% in negative cases and 55.26% in positive cases,respectively（P0.05）.Conclusion：CD44s,CD44v6,CD44v3 might play important roles in metastasis of colorectal carcinoma.
出处
《现代肿瘤医学》
CAS
2011年第3期490-494,共5页
Journal of Modern Oncology
