摘要
目的探讨高血压、体质指数(BMI)与临床术后良性前列腺增生(BPH)的关系。方法采用病例对照研究方法,病例为55～90岁临床诊断为BPH、施行手术治疗、术后病理证实为BPH的患者;对照为同期住院的非前列腺增生患者,年龄与病例相同;病例与对照各380例,以1∶1匹配;采用自行设计的调查表对研究对象进行调查,内容包括一般情况、身体测量、生活方式、既往史以及BPH家族史等,采用Logistic回归模型计算OR值及其相应的95%CI。结果调整年龄因素后,与收缩压正常者(<140 mmHg),(1 mmHg=0.133 3 kPa)相比较,收缩压160～179 mm-Hg者和收缩压≥180 mmHg者发生BPH的危险性明显增加(分别为OR=2.135,95%CI=1.139～4.001和OR=2.704,95%CI=1.475～4.958);高血压病程与BPH呈正相关(χ2=8.876,P=0.031),病程≥20年组发生BPH的危险性明显增加(OR=4.984,95%CI=2.006～12.203,P=0.001)。与非高血压者比较,超重或肥胖者罹患高血压发生BPH的危险性明显地增高(OR=2.548,95%CI=1.397～4.648和OR=2.667,95%CI=1.038～13.212)。结论高血压是BPH发病的危险因素;长期罹患高血压、尤其是高收缩压状态能够促进BPH的发生和发展;超重和肥胖的男性高血压BPH的危险性明显增加。
Objective To investigate the association between hypertension,body mass index（BMI） and clinical benign prostatic hyperplasia（BPH）. Methods A hospital-based 1∶1 matched case-control study was conducted,including the men（55-90 years old） who were surgically treated for BPH between 2007 and 2009（n=380） and the controls who were admitted to the same hospital with different diseases not related to prostatic conditions.All subjects were interviewed during their hospitalization with a structured interviewer-administered questionnaire including information on socio-demographic characteristics,lifestyle,detailed medical history,and family history of BPH in first-degree relatives.Odds ratios（ORs） and corresponding 95% confidence intervals（95%CI） were estimated with conditional logistic regression model. Results After adjusted for age,systolic blood pressure was positively related to BPH surgery only among the men with a systolic blood pressure of 160-179 mmHg and 180 mmHg or more（OR=2.135,95%CI：1.139-4.001 and OR=2.704,95%CI：1.475-4.958,respectively）.The duration of hypertension was positively related with BPH（χ2=8.876,P=0.031）,especially for 20 years or more（OR=4.948,95%CI：2.006-12.203;P=0.001）.For men of overweight（body mass index：24.0-27.9） or obesity（BMI≥28.0）,hyrertention was associated with a significantly increased risk for surgically treated BPH（compared with the subjects without hypertension（OR=2.548,95%CI：1.397-4.648 and OR=2.667,95%CI：1.038-13.212,respectively）. Conclusion Hypertension is a risk factor for BPH.A long-term hypertension,particularly the high systolic blood pressure may promote the occurrence and progression of BPH.For men of overweight or obesity,hypertension is associated with a significantly increased risk for surgically treated BPH.
出处
《中国公共卫生》
CAS
CSCD
北大核心
2011年第4期505-507,共3页
Chinese Journal of Public Health
基金
辽宁省教育厅基金项目(2008424)
关键词
良性前列腺增生
高血压
体质指数
benign prostatic hyperplasia
hypertension
body mass index
